Biodegradable cationic PEG-PEI-PBLG hyperbranched block copolymer: synthesis and micelle characterization
文献类型：期刊论文
| 作者 | Tian, HY; Deng, C; Lin, H; Sun, JR; Deng, MX; Chen, XS; Jing, XB |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2005-07-01 |
| 卷号 | 26期号:20页码:4209-4217 |
| 关键词 | Polyethylenimine Biodegradable Hyperbranched Amphiphilic Copolymer Micelle Complex Micelle Drug Delivery |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2004.11.002 |
| 英文摘要 | A novel amphiphilic biodegradable cationic hyperbranched poly(ethylene glycol)-polyethylenimine-poly(gamma-benzyl L-glutamate) (PEG-PEI-PBLG) block copolymer was successfully synthesized by ring-opening polymerization (ROP) of N-carboxyanhydride of gamma-benzyl-L-glutamate (BLG-NCA) with PEG-PEI as a macroinitiator. PEG-PEI was firstly prepared by coupling of PEG and PEI using hexamethylene diisocyanate (HMDI). The structural properties of PEG-PEI-PBLG copolymers were confirmed by H-1 NMR and GPC. The copolymers were found to be self-assembled in water with critical micelle concentration (CMC) in the range of 0.00368-0.0125 g/l and high hydrophobic micelle core. The micelle size and CMC obviously depended on the hydrophobic block content in the copolymer and the ionic state of the PEI block. The CMC decreased with the increase in the PBLG block content. The decrease of micelle size and the increase of CMC simultaneously occurred with the protonated degree of PEI block by addition of HCl solution. ESEM and Gel retardation assay showed that the cationic micelles had ability to encapsulate plasmid DNA. The copolymer has potential medical applications in drug and gene delivery. (C) 2004 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000227369000001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/56783]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen, XS |
| 作者单位 | Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, HY,Deng, C,Lin, H,et al. Biodegradable cationic PEG-PEI-PBLG hyperbranched block copolymer: synthesis and micelle characterization[J]. BIOMATERIALS,2005,26(20):4209-4217. |
| APA | Tian, HY.,Deng, C.,Lin, H.,Sun, JR.,Deng, MX.,...&Jing, XB.(2005).Biodegradable cationic PEG-PEI-PBLG hyperbranched block copolymer: synthesis and micelle characterization.BIOMATERIALS,26(20),4209-4217. |
| MLA | Tian, HY,et al."Biodegradable cationic PEG-PEI-PBLG hyperbranched block copolymer: synthesis and micelle characterization".BIOMATERIALS 26.20(2005):4209-4217. |
入库方式： OAI收割
来源：化学研究所
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