Preparation and properties of biodegradable microspheres containing 5-fluorouracil
文献类型：期刊论文
| 作者 | Yin, JB; Chen, HD; Luo, K; Zhuang, XL; Chen, XS; Cao, T |
| 刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
 |
| 出版日期 | 2005-06-10 |
| 卷号 | 26期号:6页码:1174-1176 |
| 关键词 | 5-fluorouracil Poly (Lactic Acide) (Pla) Poly(Lactic Acid)-Polyethylene Glycol (Pla-peg) Microspheres Nano-silica Controlled Drug-release |
| ISSN号 | 0251-0790 |
| 英文摘要 | Microspheres containing an antimetabolite drug 5-Fluorouracil were prepared from poly(lactic acide) (PLA) or poly (lactic acid)-polyethylene glycol (PLA-PEG) as the carrier by using a water-in-oil-in-water emulsion solvent evaporation technique. The conditions of the microspheres preparation such as Poly- mer concentration in organic solvent, relative molecular weight of PLA-PEG and PLA/PEG mass ratio were discussed. The surface morphology and the size of the microspheres were observed by SEM. The drug content of microspheres was examined by TGA and the drug release in vitro was evaluated. According to the results, the drug content increased with the nano-silica used. The highest drug content in this study was 39.9%. The drug-release kinetics satisfied the requirements of controlled drug-release. |
| 语种 | 英语 |
| WOS记录号 | WOS:000230072500047 |
| 出版者 | HIGHER EDUCATION PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/57059]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen, XS |
| 作者单位 | 1.Shanghai Univ, Dept Polymer Mat, Shanghai 201800, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, JB,Chen, HD,Luo, K,et al. Preparation and properties of biodegradable microspheres containing 5-fluorouracil[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2005,26(6):1174-1176. |
| APA | Yin, JB,Chen, HD,Luo, K,Zhuang, XL,Chen, XS,&Cao, T.(2005).Preparation and properties of biodegradable microspheres containing 5-fluorouracil.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,26(6),1174-1176. |
| MLA | Yin, JB,et al."Preparation and properties of biodegradable microspheres containing 5-fluorouracil".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 26.6(2005):1174-1176. |
入库方式： OAI收割
来源：化学研究所
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