Impact of inhibiting activity of indole inhibitors on phospholipid hydrolysis by phospholipase A(2)
文献类型：期刊论文
| 作者 | Zhai, XH; Brezesinski, G; Mohwald, H; Li, JB |
| 刊名 | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
 |
| 出版日期 | 2005-04-01 |
| 卷号 | 256期号:1页码:51-55 |
| 关键词 | Indole Pla(2) Catalyzed |
| ISSN号 | 0927-7757 |
| DOI | 10.1016/j.colsurfa.2004.09.016 |
| 英文摘要 | The influence of two indole inhibitors on the hydrolysis reaction of L-dipalmitoylphosphatidylcholine (L-DPPC) catalyzed by phospholipase A(2) (PLA(2)) has been studied in the coexistence region using surface pressure as function of time (pi-t) and Brewster angle microscopy (BAM) measurements. Similar experiments have been performed with L-DPPC vesicles made by ultrasonication method using transmission electron microscopy (TEM). Comparing the pi-t curves and BAM images, which show defected domains after a certain reaction time, as well as TEM images of defected vesicles, one can conclude that the two indole inhibitors have different abilities in reducing the activity of PLA2. The described experiments show that BAM and TEM can be successfully used to study the influence of newly designed inhibitors on the hydrolysis reaction catalyzed by PLA(2). (c) 2004 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000227940100008 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/57137]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Brezesinski, G |
| 作者单位 | 1.Max Planck Inst Colloids & Interfaces, D-14476 Potsdam, Germany 2.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Int Joint Lab,Key Lab Colloid & Interface Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhai, XH,Brezesinski, G,Mohwald, H,et al. Impact of inhibiting activity of indole inhibitors on phospholipid hydrolysis by phospholipase A(2)[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2005,256(1):51-55. |
| APA | Zhai, XH,Brezesinski, G,Mohwald, H,&Li, JB.(2005).Impact of inhibiting activity of indole inhibitors on phospholipid hydrolysis by phospholipase A(2).COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,256(1),51-55. |
| MLA | Zhai, XH,et al."Impact of inhibiting activity of indole inhibitors on phospholipid hydrolysis by phospholipase A(2)".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 256.1(2005):51-55. |
入库方式： OAI收割
来源：化学研究所
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