Effects of stereoregularity of multiblock copoly(rac-lactide)s on stereocomplex microparticles and their insulin delivery
文献类型：期刊论文
| 作者 | Hu, JL; Tang, JH; Qiu, XY; Han, YD; Liu, Q; Chen, XS; Jing, XB |
| 刊名 | MACROMOLECULAR BIOSCIENCE
 |
| 出版日期 | 2005-12-15 |
| 卷号 | 5期号:12页码:1193-1199 |
| 关键词 | Drug Delivery Systems Microparticles Stereocomplexes Stereoregularity Stereospecific Polymers |
| ISSN号 | 1616-5187 |
| 英文摘要 | Uniform stereocomplex microparticles ranging from nanometer to micrometer size are prepared by using stereo multiblock copoly(rac-lactide)s (smb-PLAs) with different stereoregularity. At comparable molecular weights, as the smb-PLA stereoregularity decreases from 88% to 76%, the crystallinity of the microparticles decreases noticeably, as proved by DSC and WAXD. At the same time, the shape of the microparticles varies from the flower shape to the sphere shape and the particle size increases markedly from 7002700 as shown by SEM. However, all insulin-loaded microparticles are of cake-shape and their sizes depend on the stereoregularity. The crystallization of smb-PLAs facilitated by insulin is evidenced by the increase of T-m and Delta H-f in DSC. The highest insulin-loading content of 14.2% and -entrapment efficiency of 82.8% are obtained from the smb-PLA with the highest stereoregularity of 88%. Release studies in vitro show the least first-day release at about 25% followed by continuous release of another 70% of insulin over one month. Stereocomplex microparticles of smb-PLAs with lower stereoregularity resulted in a relatively lower insulin-entrapment efficiency and -loading content, a larger first-day release, and also complete release of 90% of the total amount within one month. The release system follows a diffusion mechanism. By contrast, atactic PLA shows a very low entrapment efficiency of 16.7%. |
| 语种 | 英语 |
| WOS记录号 | WOS:000234465200005 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/57563]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen, XS |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, JL,Tang, JH,Qiu, XY,et al. Effects of stereoregularity of multiblock copoly(rac-lactide)s on stereocomplex microparticles and their insulin delivery[J]. MACROMOLECULAR BIOSCIENCE,2005,5(12):1193-1199. |
| APA | Hu, JL.,Tang, JH.,Qiu, XY.,Han, YD.,Liu, Q.,...&Jing, XB.(2005).Effects of stereoregularity of multiblock copoly(rac-lactide)s on stereocomplex microparticles and their insulin delivery.MACROMOLECULAR BIOSCIENCE,5(12),1193-1199. |
| MLA | Hu, JL,et al."Effects of stereoregularity of multiblock copoly(rac-lactide)s on stereocomplex microparticles and their insulin delivery".MACROMOLECULAR BIOSCIENCE 5.12(2005):1193-1199. |
入库方式： OAI收割
来源：化学研究所
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