Small angle X-ray scattering (SAXS) and differential scanning calorimetry (DSC) studies of amide phospholipid
文献类型：期刊论文
| 作者 | Zhai, XH; Bartel, M; Brezesinski, G; Rattay, B; Mohwald, H; Li, JB |
| 刊名 | CHEMISTRY AND PHYSICS OF LIPIDS
 |
| 出版日期 | 2005 |
| 卷号 | 133期号:1页码:79-88 |
| 关键词 | Amide Phospholipids Small Angle X-ray Scattering (Saxs) Differential Scanning Calorimetry (Dsc) Phase Transition Lamellar Phases |
| ISSN号 | 0009-3084 |
| DOI | 10.1016/j.chemphyslip.2004.09.013 |
| 英文摘要 | Varying chemically the structure of phospholipids in the region between hydrophobic and hydrophilic segments is expected to have a strong influence on the interaction with water and the phase behavior. This is studied in this work with the motivation to investigate these lipids as potential inhibitors of phospholipase A(2). Thus the amide phospholipids (L)-ether-amide-PC (l-O-hexadecyl-2-N-paimitoyl-2-amino-2-deoxy-sn-glycero-3-phosphocholine), L-ester-amide-PC (1-palmitoyl-2N-palmitoyl-2-amino-2-deoxy-sn-glycero-3-phosphocholine) and L-ether-amide-PE (1-O-hexadecyl-2-N-palmitoyl-2-deoxysn-glycero-3-phosphoethanolan-tine) have been synthesized and characterized. The phase behavior and thermal transitions in buffer dispersions are examined by a combination of high-sensitivity differential scanning calorimetry (DSC) and small angle X-ray scattering (SAXS) experiments between 10 and 80degreesC at pH 8.9. The onset temperatures determined from DSC measurements agree well with the starting temperatures of changes in the repeat distance obtained by SAXS measurements. The phases observed are lamellar both below and above the main phase transition. The phase transition temperatures and enthalpies depend strongly on the substitutions in sn-1 position and head group structure. The lamellar repeat distance in gel and liquid-crystalline phases increases with increasing temperature for L-ester-amide-PC and L-ether-amicle-PC, whereas the temperature dependence is opposite for the L-ether-amide-PE. The observed behavior is discussed and compared with that of DPPC and DPPE, indicating the strong dependence of hydration and phase behavior on head group structure. (C) 2004 Elsevier Ireland Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000226435900007 |
| 出版者 | ELSEVIER SCI IRELAND LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/57779]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Brezesinski, G |
| 作者单位 | 1.Max Planck Inst Colloids & Interfaces, D-14476 Golm, Germany 2.Chinese Acad Sci, Inst Chem, Int Joint Lab, Key Lab Colloid & Interface Sci,Ctr Mol Sci, Beijing 100080, Peoples R China 3.Univ Halle Wittenberg, Inst Pharmaceut Chem, D-06120 Halle Saale, Germany |
| 推荐引用方式 GB/T 7714 | Zhai, XH,Bartel, M,Brezesinski, G,et al. Small angle X-ray scattering (SAXS) and differential scanning calorimetry (DSC) studies of amide phospholipid[J]. CHEMISTRY AND PHYSICS OF LIPIDS,2005,133(1):79-88. |
| APA | Zhai, XH,Bartel, M,Brezesinski, G,Rattay, B,Mohwald, H,&Li, JB.(2005).Small angle X-ray scattering (SAXS) and differential scanning calorimetry (DSC) studies of amide phospholipid.CHEMISTRY AND PHYSICS OF LIPIDS,133(1),79-88. |
| MLA | Zhai, XH,et al."Small angle X-ray scattering (SAXS) and differential scanning calorimetry (DSC) studies of amide phospholipid".CHEMISTRY AND PHYSICS OF LIPIDS 133.1(2005):79-88. |
入库方式： OAI收割
来源：化学研究所
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