Interactions of hypocrellin B with hyaluronan and photo-induced interactions
文献类型：期刊论文
| 作者 | Song, LM; Zhao, BZ; Xie, H; Zhao, JQ |
| 刊名 | BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
 |
| 出版日期 | 2006-03-01 |
| 卷号 | 1760期号:3页码:333-339 |
| 关键词 | Environmentally Sensitive Fluorescence Of Hb Polysaccharide Hya Specific Interaction Intermolecular Hydrogen Bond |
| ISSN号 | 0304-4165 |
| DOI | 10.1016/j.bbagen.2006.01.001 |
| 英文摘要 | In the current work, the molecular recognition and interaction were studied by taking advantages of the environmentally sensitive fluorescence of hypocrellin B (HB) and the structural knowledge of hyaluronan (HYA), a polysaccharide over-expressed in tumor cells or tissues. Interestingly, it was found that, binding to HYA, the absorbance of HB would be greatly strengthened, suggesting HB fitting to a hydrophobic environment in HYA, while the fluorescence seriously quenched at pH 7.0, which was very distinct from the binding of HB to proteins, liposome, other polysaccharide molecules or HYA at pH 2.0. Synchronously, the particle size of HYA would become bigger after interaction with FIB, suggesting an aggregation of HYA. Considering the spectral responses of HB and the particle size change of HYA, a specific interaction of HB with HYA was proposed, that is, an HB molecule would link two HYA molecules not only by hydrophobic interaction but also by formations of intermolecular hydrogen bonds at physiological pH values. Furthermore the estimated binding constant suggests a quite high affinity of HB to HYA. Besides, an oxygen-dependent degradation of HYA and photobleaching of HB were observed via photosensitization of HB. (C) 2006 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000236494000005 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/58115]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhao, JQ |
| 作者单位 | Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Key Lab Photochem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, LM,Zhao, BZ,Xie, H,et al. Interactions of hypocrellin B with hyaluronan and photo-induced interactions[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,2006,1760(3):333-339. |
| APA | Song, LM,Zhao, BZ,Xie, H,&Zhao, JQ.(2006).Interactions of hypocrellin B with hyaluronan and photo-induced interactions.BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,1760(3),333-339. |
| MLA | Song, LM,et al."Interactions of hypocrellin B with hyaluronan and photo-induced interactions".BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1760.3(2006):333-339. |
入库方式： OAI收割
来源：化学研究所
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