Porcine-derived xenogeneic bone/poly(glycolide-co-lactide-co-caprolactone) composite and its affinity with rat OCT-1 osteoblast-like cells
文献类型：期刊论文
| 作者 | Qu, X; Wan, YQ; Zhang, HW; Cui, WJ; Bei, JZ; Wang, SG |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2006 |
| 卷号 | 27期号:2页码:216-225 |
| 关键词 | Porcine-derived Xenogeneic Bone Pglc Composite Osteoblast-like Cell Cell Affinity Surface Topography |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2005.05.101 |
| 英文摘要 | Porcine-derived xenogeneic bone (PDXB) was derived from cancellous bone of adult porcine. Its morphology and structure were characterized by SEM, FTIR and XRD. A series of composite films consisting of PDXB and poly(glycolide-co-lactide-cocaprolactone) (PGLC) polymer were prepared. Because of the introduction of PGLC polymer, the PDXB/PGLC composites especially PDXB/PGLC(30/70) and PDXB/PGLC(50/50) showed good processability and mechanical properties. In addition, the hydrophilicity of the composites was enhanced as well since the PDXB component was hydrophilic. Osteoblast-like cells (OCT-1) were used as an in-vitro model to assess the affinity of the PDXB/PGLC composites. It was found that compared with the pure PGLC film, PDXB/PGLC(30/70) and PDXB/PGLC(50/50) composite films promoted cell attachment, proliferation and ALP (alkaline phosphatase) activity obviously. In addition, the cells preferred growing on the areas of exposed PDXB. It was considered that the hydrophilicity, osteoconductivity and appropriate surface roughness (Sa = 3.30, 4.00 mu m) induced by PDXB facilitate cell growth. However, the introduction of too much PDXB, such as PDXB/PGLC(70/30) film, would obtain an adverse effect on the cell growth since the value of S-a was up to 7.33 mu m. It indicated that only the composites with appropriate surface topography could favor cell growth. Surface topography probably has a more important effect on cell growth process than surface chemistry. (c) 2005 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000232517900010 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/58341]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, SG |
| 作者单位 | Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qu, X,Wan, YQ,Zhang, HW,et al. Porcine-derived xenogeneic bone/poly(glycolide-co-lactide-co-caprolactone) composite and its affinity with rat OCT-1 osteoblast-like cells[J]. BIOMATERIALS,2006,27(2):216-225. |
| APA | Qu, X,Wan, YQ,Zhang, HW,Cui, WJ,Bei, JZ,&Wang, SG.(2006).Porcine-derived xenogeneic bone/poly(glycolide-co-lactide-co-caprolactone) composite and its affinity with rat OCT-1 osteoblast-like cells.BIOMATERIALS,27(2),216-225. |
| MLA | Qu, X,et al."Porcine-derived xenogeneic bone/poly(glycolide-co-lactide-co-caprolactone) composite and its affinity with rat OCT-1 osteoblast-like cells".BIOMATERIALS 27.2(2006):216-225. |
入库方式： OAI收割
来源：化学研究所
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