New long-wavelength ethanolamino-substituted hypocrellin: photodynamic activity and toxicity to MGC803 cancer cell
文献类型：期刊论文
| 作者 | Lee, HY; Zhou, ZX; Chen, S; Zhang, MH; Shen, T |
| 刊名 | DYES AND PIGMENTS
 |
| 出版日期 | 2006 |
| 卷号 | 68期号:1页码:1-10 |
| 关键词 | Ethanolamino-substituted Hypocrellin b Epr Spectra Phototoxicity Singlet Oxygen Superoxide Anion Radical |
| ISSN号 | 0143-7208 |
| DOI | 10.1016/j.dyepig.2004.06.023 |
| 英文摘要 | To improve hydrophilicity and photoactivity of the new type of therapeutic agent, hypocrellin, a novel long-wavelength ethanolamino-substituted hypocrellin B (EAHB) was synthesized and its molecular structure was characterized by IR, NMR, MS, and UV-vis spectrometers, and EAHB had strong absorption at the phototherapeutic window (600-900 nm). Illumination of deoxygenated DMSO solution containing EAHB generated a strong electron paramagnetic resonance (EPR) signal, which was assigned to the semiquinone anion radical of EAHB (EAHB(._)). Absorption measurements displayed that the absorptive bands at 632 and 565 nm (shoulder) arose from the semiquinone anion radical (EAHB(._)) and the absorptive bands at 519 and 450 nm (shoulder) belonged to hydroquinone (EAHBH(2)), which were formed via the decay of EAHB(._) in water-contained solution. Superoxide anion radical (O-2(._)) was produced via electron transfer from EAHB(._) (the precursor) to ground state oxygen. The presence of NADH, a bio-electron donor, significantly enhanced production of EAHB(._) and O-2(._) Singlet oxygen O-2 ((1)Delta(g)) could be produced via energy transfer from triplet EAHB to ground state oxygen molecules. The quantum yield Of O-2 ((1)Delta(g)) and the relative quantum yield Of O-2(_)._ of EAHB were 0.15 and 0.76, respectively, with the parent compound hypocrellin B (HB) as the standard. It was inferred that Type I pathway was possibly a major photodynamic mechanism of EAHB. The study on photobiological action of EAHB on MGC803 cancer cells revealed that EAHB kept the same good phototoxic ability as HB but reduced 4 times cytotoxicity than HB, and also its photopotentiation factor increased 4-folds. (c) 2005 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000232169400001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/58355]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang, MH |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Key Lab Photochem, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lee, HY,Zhou, ZX,Chen, S,et al. New long-wavelength ethanolamino-substituted hypocrellin: photodynamic activity and toxicity to MGC803 cancer cell[J]. DYES AND PIGMENTS,2006,68(1):1-10. |
| APA | Lee, HY,Zhou, ZX,Chen, S,Zhang, MH,&Shen, T.(2006).New long-wavelength ethanolamino-substituted hypocrellin: photodynamic activity and toxicity to MGC803 cancer cell.DYES AND PIGMENTS,68(1),1-10. |
| MLA | Lee, HY,et al."New long-wavelength ethanolamino-substituted hypocrellin: photodynamic activity and toxicity to MGC803 cancer cell".DYES AND PIGMENTS 68.1(2006):1-10. |
入库方式： OAI收割
来源：化学研究所
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