pH controlled permeability of lipid/protein biomimetic microcapsules
文献类型：期刊论文
| 作者 | An, ZH; Mohwald, H; Li, JB |
| 刊名 | BIOMACROMOLECULES
 |
| 出版日期 | 2006-02-01 |
| 卷号 | 7期号:2页码:580-585 |
| ISSN号 | 1525-7797 |
| DOI | 10.1021/bm050641s |
| 英文摘要 | The permeability of lipid and protein microcapsules fabricated by alternating adsorption of human serum albumin (HSA) and L-alpha-dimyristoylphosphatidic acid (DMPA) on a template and subsequent removal of the core is studied as a function of pH value and supplementary layers. The capsules were permeable for macromolecules (FITC-labeled dextran, M-w 40 kDa) at pH < 4.8 and impermeable at pH > 7.4. The assembly of supplementary DMPA bilayers rendered the capsules impermeable for small hydrophilic molecules such as 6-carboxyfluorescein (6-CF). Hence DMPA/HSA capsules can be resealed after fabrication by supplementary layers. This provides the opportunity of applying such biomimetic membrane capsules as drug carriers or model systems to study biological processes at membranes. |
| 语种 | 英语 |
| WOS记录号 | WOS:000235538600026 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/58369]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, JB |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Int Joint Lab, Key Lab Colloid & Interface Sci,Ctr Mol Sci, Beijing 100080, Peoples R China 2.Max Planck Inst Colloids & Interfaces, D-14476 Golm Potsdam, Germany |
| 推荐引用方式 GB/T 7714 | An, ZH,Mohwald, H,Li, JB. pH controlled permeability of lipid/protein biomimetic microcapsules[J]. BIOMACROMOLECULES,2006,7(2):580-585. |
| APA | An, ZH,Mohwald, H,&Li, JB.(2006).pH controlled permeability of lipid/protein biomimetic microcapsules.BIOMACROMOLECULES,7(2),580-585. |
| MLA | An, ZH,et al."pH controlled permeability of lipid/protein biomimetic microcapsules".BIOMACROMOLECULES 7.2(2006):580-585. |
入库方式： OAI收割
来源：化学研究所
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