Intravitreal implantation of the biodegradable cyclosporin A drug delivery system for experimental chronic uveitis
文献类型：期刊论文
| 作者 | Dong, XG; Shi, WY; Yuan, GQ; Xie, LX; Wang, SG; Lin, P |
| 刊名 | GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
 |
| 出版日期 | 2006-04-01 |
| 卷号 | 244期号:4页码:492-497 |
| 关键词 | Uveitis Cyclosporin a Pglc Drug Delivery System |
| ISSN号 | 0721-832X |
| DOI | 10.1007/s00417-005-0109-1 |
| 英文摘要 | Purpose: The purpose was to evaluate the efficacy of the intravitreal implantation of the biodegradable cyclosporin A (CsA) drug delivery system (DDS) for experimental chronic uveitis. Methods: The DDS was prepared by formulating CsA into glycolide-co-lactide-co-caprolactone copolymer (PGLC). Right eyes of 30 New Zealand white rabbits were used to establish a model of uveitis and randomized into control, intravitreal non-medicated DDS, oral CsA (15 mg/kg daily), and intravitreal CsA-PGLC DDS (each containing 2 mg CsA) groups. The progress of ocular inflammation, results of electroretinography, and histopathological examination of ocular, renal, and hepatic functions were recorded. Intravitreal CsA levels were measured in another 13 rabbits receiving an implant of the CsA-PGLC DDS. Results: Chronic uveitis was successfully induced in all 30 eyes. The inflammation in the eyes with no treatment, non-medicated implant, and oral CsA was more severe than those with the CsA-PGLC DDS at each timepoint. The electroretinography b-wave was depressed much less in the CsA-PGLC DDS group than in the other three groups (p < 0.05). No renal or hepatic tissue damage was found in eyes with the CsA-PGLC DDS. The mean intravitreal CsA level was 102.2 similar to 145.5 ng/ml at 1 similar to 3 weeks after CsA-PGLC DDS implantation, 491.0 similar to 575.2 ng/ml at 4 similar to 10 weeks, and 257.3 ng/ml at 14 weeks; no toxicity was detected. Conclusions: Intravitreal implantation of the biodegradable CsA-PGLC DDS may effectively reduce the intraocular inflammation in rabbits with no toxicity, which provides a potentially safe and convenient approach for the treatment of chronic uveitis. |
| 语种 | 英语 |
| WOS记录号 | WOS:000236752500011 |
| 出版者 | SPRINGER |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/58587]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Xie, LX |
| 作者单位 | 1.Shandong Eye Inst, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, XG,Shi, WY,Yuan, GQ,et al. Intravitreal implantation of the biodegradable cyclosporin A drug delivery system for experimental chronic uveitis[J]. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,2006,244(4):492-497. |
| APA | Dong, XG,Shi, WY,Yuan, GQ,Xie, LX,Wang, SG,&Lin, P.(2006).Intravitreal implantation of the biodegradable cyclosporin A drug delivery system for experimental chronic uveitis.GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,244(4),492-497. |
| MLA | Dong, XG,et al."Intravitreal implantation of the biodegradable cyclosporin A drug delivery system for experimental chronic uveitis".GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 244.4(2006):492-497. |
入库方式： OAI收割
来源：化学研究所
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