Micellar liquid chromatography study of quantitative retention-activity relationships for antihypertensive drugs
文献类型：期刊论文
| 作者 | Wang, Sumin; Yang, Gengliang; Li, Zhiwei; Liu, Haiyan; Bai, Jie; Zhang, Yihua |
| 刊名 | CHROMATOGRAPHIA
 |
| 出版日期 | 2006-07-01 |
| 卷号 | 64期号:1-2页码:23-29 |
| 关键词 | Column Liquid Chromatography Micellar Lc Quantitative Retention-activity Relationship Pharmacodynamic Data Antihypertensive Drugs |
| ISSN号 | 0009-5893 |
| DOI | 10.1365/s10337-006-0811-0 |
| 英文摘要 | Use of micellar mobile phases in reversed-phase liquid chromatography (RPLC) results in hydrophobic and electrostatic sites for interaction. Modified stationary phases in micellar liquid chromatography (MLC) are structurally similar to biomembranes. To confirm this we focused on the effects of the type and concentration of surfactant (Brij 35, SDS, and CTAB) and mobile phase pH on the retention of anti hypertensive drugs on modified C-18 stationary phases. Quantitative retention-activity relationships are proposed for the drugs and the different surfactants and compared with those obtained using aqueous-organic mobile phases. Finally, a correlation was obtained between the logarithm of retention factors (log k) and the toxicity (LD50) of antihypertensive drugs. |
| 语种 | 英语 |
| WOS记录号 | WOS:000239677700004 |
| 出版者 | VIEWEG |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/59035]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yang, Gengliang |
| 作者单位 | 1.Hebei Univ, Coll Pharm, Baoding 071002, Peoples R China 2.Hebei Med Univ, Dept Pharmacol, Shijiazhuang 050017, Peoples R China 3.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China 4.Handan Univ, Dept Chem, Handan 056005, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Sumin,Yang, Gengliang,Li, Zhiwei,et al. Micellar liquid chromatography study of quantitative retention-activity relationships for antihypertensive drugs[J]. CHROMATOGRAPHIA,2006,64(1-2):23-29. |
| APA | Wang, Sumin,Yang, Gengliang,Li, Zhiwei,Liu, Haiyan,Bai, Jie,&Zhang, Yihua.(2006).Micellar liquid chromatography study of quantitative retention-activity relationships for antihypertensive drugs.CHROMATOGRAPHIA,64(1-2),23-29. |
| MLA | Wang, Sumin,et al."Micellar liquid chromatography study of quantitative retention-activity relationships for antihypertensive drugs".CHROMATOGRAPHIA 64.1-2(2006):23-29. |
入库方式： OAI收割
来源：化学研究所
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