On-line simultaneous removal of human serum albumin and enrichment. of doxazosin using a weak cation-exchange monolithic column
文献类型：期刊论文
| 作者 | Yang, Gengliang; Liu, Haiyan; Zhang, Yihua; Wang, Sumin; Yin, Junfa; Yin, Boying; Chen, Yi |
| 刊名 | JOURNAL OF CHROMATOGRAPHY A
 |
| 出版日期 | 2006-10-06 |
| 卷号 | 1129期号:2页码:231-235 |
| 关键词 | Monolithic Column Solid-phase Extraction Deproteinization Doxazosin Human Plasma Cation Exchange |
| ISSN号 | 0021-9673 |
| DOI | 10.1016/j.chroma.2006.07.029 |
| 英文摘要 | A weak cation-exchange monolithic column was prepared by modifying the GMA-EDMA (glycidyl methacrylate-co-ethylene glycol dimethacrylate) monoliths with ethylenediamine and monochloracetic acid. The properties of the column were investigated; the column exhibited the ability of low backpressure and fast analysis. Using this monolithic column, trace doxazosin in human serum albumin (HSA) solution and plasma samples has been on-line tested, the extraction efficiency and the maximum loading capacity of the monolithic column were obtained. The results showed that the monolithic column could realize deproteinization and trace drug enrichment simultaneously in the HSA solution and human plasma, which provided a simple, cheap, effective and friendly to environment method for assaying drugs in the blood. (c) 2006 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000240879200010 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/59199]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yang, Gengliang |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China 2.Hubei Univ, Coll Pharm, Baoding 071002, Peoples R China 3.Hubei Med Univ, Dept Pharmacol, Shijiazhuang 050017, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Gengliang,Liu, Haiyan,Zhang, Yihua,et al. On-line simultaneous removal of human serum albumin and enrichment. of doxazosin using a weak cation-exchange monolithic column[J]. JOURNAL OF CHROMATOGRAPHY A,2006,1129(2):231-235. |
| APA | Yang, Gengliang.,Liu, Haiyan.,Zhang, Yihua.,Wang, Sumin.,Yin, Junfa.,...&Chen, Yi.(2006).On-line simultaneous removal of human serum albumin and enrichment. of doxazosin using a weak cation-exchange monolithic column.JOURNAL OF CHROMATOGRAPHY A,1129(2),231-235. |
| MLA | Yang, Gengliang,et al."On-line simultaneous removal of human serum albumin and enrichment. of doxazosin using a weak cation-exchange monolithic column".JOURNAL OF CHROMATOGRAPHY A 1129.2(2006):231-235. |
入库方式： OAI收割
来源：化学研究所
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