Preparation of poly(lactide-co-glycolide-co-caprolactone) nanoparticles and their degradation behaviour in aqueous solution
文献类型：期刊论文
| 作者 | Zhang, Hanwei; Cui, Wenjin; Bei, Jianzhong; Wang, Shenguo |
| 刊名 | POLYMER DEGRADATION AND STABILITY
 |
| 出版日期 | 2006-09-01 |
| 卷号 | 91期号:9页码:1929-1936 |
| 关键词 | Nanoparticles Poly(Lactide-co-glycolide-co-caprolactone) Spontaneous Emulsification Solvent Diffusion Method (Sesm Method) In Vitro Degradation |
| ISSN号 | 0141-3910 |
| DOI | 10.1016/j.polymdegradstab.2006.03.004 |
| 英文摘要 | The tri-component copolymer poly(lactide-co-glycolide-co-caprolactone) (PLGC) was synthesized to prepare nanoparticles by the modifiedspontaneous emulsification solvent diffusion method (modified-SESD method); and the method was also modified by using the Tween60 instead of poly(vinyl alcohol) (PVA) as dispersing agent. The obtained nanoparticles have spherical shape and good particle distribution with mean size in the range from 100 to 200 nm. The in vitro degradation behaviour of PLGC nanoparticles was investigated. It was found that PLGC nanoparticles could remain stable during the degradation with no agglomeration. Compared with PLA and PLGA nanoparticles, the degradation rate of PLGC nanoparticles is faster. After 9 weeks of hydrolysis, the M. of PLGC is less by 10% of the original M-n. The mean radius of the nanoparticles increases from 68 nm to 80 nm continuously during the first stage, and after 4 weeks of degradation, the particles' size decreases gradually from 80 nm to about 40 nm. These results suggest that the PLGC nanoparticles may show degradation-controlled drug release behaviour and seem to be a promising drug delivery system. (c) 2006 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000238918200003 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/59451]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Shenguo |
| 作者单位 | Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Inst Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Hanwei,Cui, Wenjin,Bei, Jianzhong,et al. Preparation of poly(lactide-co-glycolide-co-caprolactone) nanoparticles and their degradation behaviour in aqueous solution[J]. POLYMER DEGRADATION AND STABILITY,2006,91(9):1929-1936. |
| APA | Zhang, Hanwei,Cui, Wenjin,Bei, Jianzhong,&Wang, Shenguo.(2006).Preparation of poly(lactide-co-glycolide-co-caprolactone) nanoparticles and their degradation behaviour in aqueous solution.POLYMER DEGRADATION AND STABILITY,91(9),1929-1936. |
| MLA | Zhang, Hanwei,et al."Preparation of poly(lactide-co-glycolide-co-caprolactone) nanoparticles and their degradation behaviour in aqueous solution".POLYMER DEGRADATION AND STABILITY 91.9(2006):1929-1936. |
入库方式： OAI收割
来源：化学研究所
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