Synthesis and characterization of a new water-soluble endohedral metallofullerene for MRI contrast agents
文献类型：期刊论文
| 作者 | Shu, CY; Gan, LH; Wang, CR; Pei, XL; Han, HB |
| 刊名 | CARBON
 |
| 出版日期 | 2006-03-01 |
| 卷号 | 44期号:3页码:496-500 |
| 关键词 | Fullerene Magnetic Properties X-ray Photoelectron Spectroscopy Electronic Structure Aggregation |
| ISSN号 | 0008-6223 |
| DOI | 10.1016/j.carbon.2005.08.016 |
| 英文摘要 | Water-soluble amino acid derivatives of gadolinium (Gd) endohedral metallofullerenes (AAD-EMFs), Gd@C82Om(OH)(n)(NHCH2CH2COOH)(l) (m approximate to 6, n approximate to 16 and l approximate to 8) are synthesized by a direct reaction of the pure endohedral metallofullerene Gd@C-82 with an excess of alkaline solution of beta-alanine. The structure of the AAD-EMFs is characterized by FTIR, XPS and laser-desorption time-of-flight (LD-TOF) mass spectrometries. Water proton relaxivity analysis indicates that the longitudinal relaxivity R-1 (the effect on 1/T-1, 9.1 mM(-1) s(-1)) of AAD-EMFs is higher than that of the commercial MRI contrast agent, Magnevist (gadolinium-diethylenetriaminepentaacetic acid, Gd-DTPA, 5.6 mM(-1) s(-1)). The MRI phantom studies are performed to confirm the high efficiency of this sample as MRI contrast agents. (C) 2005 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000234186700015 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/59523]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, CR |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China 2.Peking Univ, Hosp 3, Dept Irradiat, Beijing 100083, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shu, CY,Gan, LH,Wang, CR,et al. Synthesis and characterization of a new water-soluble endohedral metallofullerene for MRI contrast agents[J]. CARBON,2006,44(3):496-500. |
| APA | Shu, CY,Gan, LH,Wang, CR,Pei, XL,&Han, HB.(2006).Synthesis and characterization of a new water-soluble endohedral metallofullerene for MRI contrast agents.CARBON,44(3),496-500. |
| MLA | Shu, CY,et al."Synthesis and characterization of a new water-soluble endohedral metallofullerene for MRI contrast agents".CARBON 44.3(2006):496-500. |
入库方式： OAI收割
来源：化学研究所
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