Surface modification of poly(L-lactic acid) to improve its cytocompatibility via assembly of polyelectrolytes and gelatin
文献类型：期刊论文
| 作者 | Lin, Y; Wang, LL; Zhang, PB; Wang, X; Chen, XS; Jing, XB; Su, ZH |
| 刊名 | ACTA BIOMATERIALIA
 |
| 出版日期 | 2006-03-01 |
| 卷号 | 2期号:2页码:155-164 |
| 关键词 | Poly(L-lactic Acid) Electrostatic Self-assembly Gelatin Chondrocyte Cytocompatibility |
| ISSN号 | 1742-7061 |
| DOI | 10.1016/j.actbio.2005.10.002 |
| 英文摘要 | Poly(L-lactide) (PLLA) surface was modified via aminolysis by poly(allylamine hydrochloride) (PAH) at high pH and subsequent electrostatic self-assembly of poly(sodium styrenesulfonate) (PSS) and PAH, and the process was monitored by X-ray photoelectron spectroscopy (XPS) and contact angle measurement. These modified PLLAs were then used as charged substrates for further incorporation of gelatin to improve their cytocompatibility. The amphoteric nature of the gelatin was exploited and the gelatin was adsorbed to the negatively charged PLLA/PSS and positively charged PLLA/PAH at pH = 3.4 and 7.4, respectively. XPS and water contact angle data indicated that the gelatin adsorption at pH = 3.4 resulted in much higher surface coverage by gelatin than at pH = 7.4. All the modified PLLA surfaces became more hydrophilic than the virgin PLLA. Chondrocyte culture was used to test the cell attachment, cell morphology and cell viability on the modified PLLA substrates. The results showed that the PAH and PSS modified PLLA exhibited better cytocompatibility than virgin PLLA, and the incorporation of the gelatin on these modified PLLA substrates further improved their cytocompatibility, with the PLLA/PSS substrate treated with the gelatin at pH = 3.4 being the best, exceeding the chondrocyte compatibility of the tissue culture polystyrene. (c) 2005 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000235787700003 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/59587]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Su, ZH |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Jilin Univ Technol, Dept Mat Sci & Engn, Changchun 130025, Peoples R China 3.Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Y,Wang, LL,Zhang, PB,et al. Surface modification of poly(L-lactic acid) to improve its cytocompatibility via assembly of polyelectrolytes and gelatin[J]. ACTA BIOMATERIALIA,2006,2(2):155-164. |
| APA | Lin, Y.,Wang, LL.,Zhang, PB.,Wang, X.,Chen, XS.,...&Su, ZH.(2006).Surface modification of poly(L-lactic acid) to improve its cytocompatibility via assembly of polyelectrolytes and gelatin.ACTA BIOMATERIALIA,2(2),155-164. |
| MLA | Lin, Y,et al."Surface modification of poly(L-lactic acid) to improve its cytocompatibility via assembly of polyelectrolytes and gelatin".ACTA BIOMATERIALIA 2.2(2006):155-164. |
入库方式： OAI收割
来源：化学研究所
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