Polydiacetylene vesicle - A device based on molecular assembly for biological molecular recognition
文献类型：期刊论文
| 作者 | Deng Jieli; Guo Caixin; Lu Wensheng; Liu Tao; Jiang Long |
| 刊名 | PROGRESS IN CHEMISTRY
 |
| 出版日期 | 2006-11-01 |
| 卷号 | 18期号:11页码:1397-1408 |
| 关键词 | Biosensors Pda Vesicles Immunoassay Bacterium Assay Metallic Ion detectIon Fluorescence |
| ISSN号 | 1005-281X |
| 英文摘要 | Under UV irradiation, ordered diacetylene molecules can be polymerized and form polydiacetylene (PDA) vesicle. Generally speaking, optical absorption in PDA occurs via a pi-to-pi* absorption within the linear pi-conjugated polymer backbone. When decorated with specific probe( receptors) PDA vesicles will undergo dramatic color changes from blue to red in the direct responding to the ligands on the surface of bio-molecules (eg. DNA, antibody-antigen and the bacteria) to be recognized by ligand-receptor binding at the interface and act as a "reporter" of molecular recognition. In some circumstances the red phase transition accompanies strong fluorescence. The unique chromatic properties of molecular recognition made PDA vesicles a promising biosensor and many biological species, such as virus, bacteria, lipolytic enzyme, antimicrobial peptide, mammalian peptide, ions, antibody-antigen and oligonucleotide etc. have been detected. PDA vesicles can also combine with nanogold for fabricating hollow spheres, which can be used as carrier of nanogold having a better performance for DNA immobilization, recognition and separation. With the improvement of detection conditions and influence factors, PDA vesicles of high sensitivity and high selectivity of recognition could be obtained, showing a great prospect to be applied as biosensors. |
| 语种 | 英语 |
| WOS记录号 | WOS:000242387400001 |
| 出版者 | CHINESE ACAD SCIENCES |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/59641]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Deng Jieli |
| 作者单位 | Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng Jieli,Guo Caixin,Lu Wensheng,et al. Polydiacetylene vesicle - A device based on molecular assembly for biological molecular recognition[J]. PROGRESS IN CHEMISTRY,2006,18(11):1397-1408. |
| APA | Deng Jieli,Guo Caixin,Lu Wensheng,Liu Tao,&Jiang Long.(2006).Polydiacetylene vesicle - A device based on molecular assembly for biological molecular recognition.PROGRESS IN CHEMISTRY,18(11),1397-1408. |
| MLA | Deng Jieli,et al."Polydiacetylene vesicle - A device based on molecular assembly for biological molecular recognition".PROGRESS IN CHEMISTRY 18.11(2006):1397-1408. |
入库方式： OAI收割
来源：化学研究所
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