Synthesis of trifluoromethyl-promoted functional pyrazolo [1,5-a]pyrimidine and pyrazolo [5,1-d] [1,2,3,5]tetrazine-4(3H)-ones
文献类型：期刊论文
| 作者 | Wu, YC; Chen, YJ; Li, HJ; Zou, XM; Hu, FZ; Yang, HZ |
| 刊名 | JOURNAL OF FLUORINE CHEMISTRY
 |
| 出版日期 | 2006-03-01 |
| 卷号 | 127期号:3页码:409-416 |
| 关键词 | Fluorine Pyrazole Inhibitor Pyrazolo[1 Pyrazolo[5 5-a]Pyrimidine 1-d][1 2 3 5]Tetrazine-4(3h)-one |
| ISSN号 | 0022-1139 |
| DOI | 10.1016/j.jfluchem.2006.02.001 |
| 英文摘要 | Ethyl 5-amino-3-trifluoroinethyl-1H-pyrazole-4-carboxylate (1) was efficiently synthesized via the condensation of ethyl cyanoacetate and trifluoroacetic anhydride, followed by chloridization and the condensation with aqueous hydrazine. Its unique reactivity was exploited for the synthesis of trifluoromethylated pyrazolo[1,5-a]pyrimidine (5) and pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones (8a-j). Among them, 5 was firstly found to be a novel fluorescent molecule that might be exploited as an attractive fluorophore for possessing many binding sites, and its fluorescence intensity was obviously stronger than its methyl analogue. 8 were found to be a new chemical class of potential monocotyledonous Echinochloa crus-galli L. Beauv, inhibitors, and were more active than their methyl analogues. (c) 2006 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000236926300015 |
| 出版者 | ELSEVIER SCIENCE SA |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/60003]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yang, HZ |
| 作者单位 | 1.Nankai Univ, State Key Lab Element Organ Chem, Inst Element Organ Chem, Tianjin 300071, Peoples R China 2.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, YC,Chen, YJ,Li, HJ,et al. Synthesis of trifluoromethyl-promoted functional pyrazolo [1,5-a]pyrimidine and pyrazolo [5,1-d] [1,2,3,5]tetrazine-4(3H)-ones[J]. JOURNAL OF FLUORINE CHEMISTRY,2006,127(3):409-416. |
| APA | Wu, YC,Chen, YJ,Li, HJ,Zou, XM,Hu, FZ,&Yang, HZ.(2006).Synthesis of trifluoromethyl-promoted functional pyrazolo [1,5-a]pyrimidine and pyrazolo [5,1-d] [1,2,3,5]tetrazine-4(3H)-ones.JOURNAL OF FLUORINE CHEMISTRY,127(3),409-416. |
| MLA | Wu, YC,et al."Synthesis of trifluoromethyl-promoted functional pyrazolo [1,5-a]pyrimidine and pyrazolo [5,1-d] [1,2,3,5]tetrazine-4(3H)-ones".JOURNAL OF FLUORINE CHEMISTRY 127.3(2006):409-416. |
入库方式： OAI收割
来源：化学研究所
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