Applying theoretical approach for predicting the selective calcium channel blockers pharmacological parameter by biopartitioning micellar chromatography
文献类型：期刊论文
| 作者 | Wang, SM; Yang, GL; Li, ZW; Liu, HY; Guo, HJ |
| 刊名 | CHINESE JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2006-06-01 |
| 卷号 | 24期号:6页码:755-760 |
| 关键词 | Biopartitioning Micellar Chromatography Pharmacological Parameter Selective Calcium Channel Blockers |
| ISSN号 | 1001-604X |
| 英文摘要 | The usefulness of biopartitioning micellar chromatography (BMC) for predicting oral drug acute toxicity and apparent bioavailability was demonstrated. A logarithmic model (an LD50 model) and the second order polynomial models (apparent bioavailability model) have been obtained using the retention data of the selective calcium channel blockers to predict pharmacological properties of compounds. The use of BMC is simple, reproducible and can provide key information about the acute toxicity and transport properties of new compounds during the drug discovery process. |
| 语种 | 英语 |
| WOS记录号 | WOS:000238343100007 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/60087]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, SM |
| 作者单位 | 1.Hebei Univ, Coll Pharm, Baoding 071002, Hebei, Peoples R China 2.Hebei Med Univ, Dept Pharmacol, Shijiazhuang 050017, Hebei, Peoples R China 3.Chinese Acad Sci, Ctr Mol Sci, Inst Chem, Beijing 100080, Peoples R China 4.Shijiazhuang Pharmaceut Grp, Shijiazhuang 050091, Hebei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, SM,Yang, GL,Li, ZW,et al. Applying theoretical approach for predicting the selective calcium channel blockers pharmacological parameter by biopartitioning micellar chromatography[J]. CHINESE JOURNAL OF CHEMISTRY,2006,24(6):755-760. |
| APA | Wang, SM,Yang, GL,Li, ZW,Liu, HY,&Guo, HJ.(2006).Applying theoretical approach for predicting the selective calcium channel blockers pharmacological parameter by biopartitioning micellar chromatography.CHINESE JOURNAL OF CHEMISTRY,24(6),755-760. |
| MLA | Wang, SM,et al."Applying theoretical approach for predicting the selective calcium channel blockers pharmacological parameter by biopartitioning micellar chromatography".CHINESE JOURNAL OF CHEMISTRY 24.6(2006):755-760. |
入库方式： OAI收割
来源：化学研究所
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