BCNU-loaded PEG-PLLA ultrafine fibers and their in vitro antitumor activity against glioma C6 cells
文献类型：期刊论文
| 作者 | Xu, Xiuling; Chen, Xuesi; Xu, Xiaoyi; Lu, Tiancheng; Wang, Xin; Yang, Lixin; Jing, Xiabin |
| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 2006-09-12 |
| 卷号 | 114期号:3页码:307-316 |
| ISSN号 | 0168-3659 |
| 关键词 | Bcnu Peg-plla Fibers Electrospinning Cytotoxicity |
| DOI | 10.1016/j.jconrel.2006.05.031 |
| 英文摘要 | The purpose of the present study was to develop implantable BCNU-toaded poly(ethylene glycol)poly(L-lactic acid) (PEG-PLLA) diblock copolymer fibers for the controlled release of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). BCNU was well incorporated and dispersed uniformly in biodegradable PEG-PLLA fibers by using electrospinning method. Environmental Scanning Electron Microscope (ESEM) images indicated that the BCNU-loaded PEG-PLLA fibers looked uniform and their surfaces were reasonably smooth. Their average diameters were below 1500 nm. The release rate of BCNU from the fiber mats increased with the increase of BCNU loading amount. In vitro cytotoxicity assay showed that the PEG-PLLA fibers themselves did not affect the growth of rat Glioma C6 cells. Antitumor activity of the BCNU-loaded fibers against the cells was kept over the whole experiment process, while that of pristine BCNU disappeared within 48 h. These results strongly suggest that the BCNU/PEG-PLLA fibers have an effect of controlled release of BCNU and are suitable for postoperative chemotherapy of cancers. (c) 2006 Elsevier B.V All rights reserved. |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000241177800004 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/60135]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Xiuling,Chen, Xuesi,Xu, Xiaoyi,et al. BCNU-loaded PEG-PLLA ultrafine fibers and their in vitro antitumor activity against glioma C6 cells[J]. JOURNAL OF CONTROLLED RELEASE,2006,114(3):307-316. |
| APA | Xu, Xiuling.,Chen, Xuesi.,Xu, Xiaoyi.,Lu, Tiancheng.,Wang, Xin.,...&Jing, Xiabin.(2006).BCNU-loaded PEG-PLLA ultrafine fibers and their in vitro antitumor activity against glioma C6 cells.JOURNAL OF CONTROLLED RELEASE,114(3),307-316. |
| MLA | Xu, Xiuling,et al."BCNU-loaded PEG-PLLA ultrafine fibers and their in vitro antitumor activity against glioma C6 cells".JOURNAL OF CONTROLLED RELEASE 114.3(2006):307-316. |
入库方式： OAI收割
来源：化学研究所
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