Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors
文献类型：期刊论文
| 作者 | Zhou, Lu; Liu, Ying; Zhang, Weilin; Wei, Ping; Huang, Changkang; Pei, Jianfeng; Yuan, Yaxia; Lai, Luhua |
| 刊名 | JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2006-06-15 |
| 卷号 | 49期号:12页码:3440-3443 |
| ISSN号 | 0022-2623 |
| DOI | 10.1021/jm0602357 |
| 英文摘要 | A series of isatin derivatives were synthesized and tested against SARS CoV 3C-like protease. Substitutions at the N-1 and C-5 positions were examined to elucidate the differences in substrate binding sites of the rhinovirus 3C protease and SARS CoV 3C-like protease. Compound 5f shows significant inhibition with an IC50 of 0.37 mu M. Further study showed that, unlike the irreversible covalent binding of isatin derivatives to human rhinovirus 3C protease, the compounds tested in this study are all noncovalent reversible inhibitors. |
| 语种 | 英语 |
| WOS记录号 | WOS:000238114700003 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/60221]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Ying |
| 作者单位 | 1.Peking Univ, State Key Lab Struct Chem Unstable & Stable Speci, Coll Chem & Mol Engn, Beijing 100871, Peoples R China 2.Peking Univ, Ctr Theoret Biol, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Lu,Liu, Ying,Zhang, Weilin,et al. Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors[J]. JOURNAL OF MEDICINAL CHEMISTRY,2006,49(12):3440-3443. |
| APA | Zhou, Lu.,Liu, Ying.,Zhang, Weilin.,Wei, Ping.,Huang, Changkang.,...&Lai, Luhua.(2006).Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors.JOURNAL OF MEDICINAL CHEMISTRY,49(12),3440-3443. |
| MLA | Zhou, Lu,et al."Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors".JOURNAL OF MEDICINAL CHEMISTRY 49.12(2006):3440-3443. |
入库方式： OAI收割
来源：化学研究所
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