A novel polymer-paclitaxel conjugate based on amphiphilic triblock copolymer
文献类型：期刊论文
| 作者 | Xie, Zhigang; Guan, Huili; Chen, Xuesi; Lu, Changhai; Chen, Li; Hu, Xiuli; Shi, Quan; Jing, Xiabin |
| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 2007-02-12 |
| 卷号 | 117期号:2页码:210-216 |
| ISSN号 | 0168-3659 |
| 关键词 | Amphiphilic Triblock Copolymer Polylactide Poly(Amino Acid) Paclitaxel |
| DOI | 10.1016/j.jconrel.2006.11.014 |
| 英文摘要 | A novel amphiphilic polymer-paclitaxel conjugate P(LGG-paclitaxel)-PEG-P(LGG-paclitaxel) has been prepared. It was derived from its parent polymer P(LGG)-PEG-P(LGG), poly {(lactic acid)-co-[(glycolic acid)-alt-(L-glutamic acid)]}-block-poly(ethylene glycol)-block-poly {(lactic acid)-co-[(glycolic acid)-alt-(L-glutamic acid)]}, which was prepared by ring-opening copolymerization of L-lactide (LLA) with (3s)-benzoxylearbonylethyl-morpholine-2,5-dione (BEMD) in the presence of dihydroxyl PEG with molecular weight of 4600 as a macroinitiator using stannous octoate (Sn(Oct)(2)) as catalyst, and by subsequent catalytic hydrogenation. It could self-assemble into micelles in an aqueous system with P(LGG-paclitaxel) block in the core and PEG in the shell. ESEM and DLS analysis of the micelles revealed a homogeneous spherical morphology and a unimodal size distribution. In vitro release of paclitaxel from the conjugate micelles showed that its release rate depended on pH value and was higher at lower pH than in neutral condition. In vitro antitumor activity of the paclitaxel conjugate against rat brain glioma C6 cells was evaluated by MTT method. The results showed that the paclitaxel can be released from the conjugate without losing cytotoxicity. (c) 2006 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000244624100009 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/60429]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Zhigang,Guan, Huili,Chen, Xuesi,et al. A novel polymer-paclitaxel conjugate based on amphiphilic triblock copolymer[J]. JOURNAL OF CONTROLLED RELEASE,2007,117(2):210-216. |
| APA | Xie, Zhigang.,Guan, Huili.,Chen, Xuesi.,Lu, Changhai.,Chen, Li.,...&Jing, Xiabin.(2007).A novel polymer-paclitaxel conjugate based on amphiphilic triblock copolymer.JOURNAL OF CONTROLLED RELEASE,117(2),210-216. |
| MLA | Xie, Zhigang,et al."A novel polymer-paclitaxel conjugate based on amphiphilic triblock copolymer".JOURNAL OF CONTROLLED RELEASE 117.2(2007):210-216. |
入库方式： OAI收割
来源：化学研究所
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