Preparation of nano-hydroxyapatite/poly(L-lactide) biocomposite microspheres
文献类型：期刊论文
| 作者 | Qiu, Xueyu; Han, Yadong; Zhuang, Xiuli; Chen, Xuesi; Li, Yuesheng; Jing, Xiabin |
| 刊名 | JOURNAL OF NANOPARTICLE RESEARCH
 |
| 出版日期 | 2007-10-01 |
| 卷号 | 9期号:5页码:901-908 |
| 关键词 | Hydroxyapatite Polylactide Composite Microsphere Surface Modification Surface Grafting Emulsion |
| ISSN号 | 1388-0764 |
| DOI | 10.1007/s11051-006-9158-6 |
| 英文摘要 | Nano-hydroxyapatite (HA)/poly(L-lactide) (PLLA) composite microspheres with relatively uniform size distribution were prepared by a solid-in-oil-in-water (s/o/w) emusion solvent evaporation method. The encapsulation of the HA nanopaticles in microshperes was significantly improved by grafting PLLA on the surface of the HA nanoparticles (p-HA) during emulsion process. This procedure gave a possibility to obtain p-HA/PLLA composite microspheres with uniform morphology and the encapsulated p-HA nanoparticle loading reached up to 40 wt% (33 wt% of pure HA) in the p-HA/PLLA composite microspheres. The microstructure of composite microspheres from core-shell to single phase changed with the variation of p-HA to PLLA ratios. p-HA/PLLA composite microspheres with the diameter range of 2-3 mu m were obtained. The entrapment efficiency of p-HA in microspheres could high up to 90 wt% and that of HA was only 13 wt%. Surface and bulk characterizations of the composite microspheres were performed by measurements such as wide angle X-ray diffraction (WAXD), thermal gravimetric analysis (TGA), environmental scanning electron microscope (ESEM) and transmission electron microscopy (TEM). |
| 语种 | 英语 |
| WOS记录号 | WOS:000247471500020 |
| 出版者 | SPRINGER |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/60447]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen, Xuesi |
| 作者单位 | Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qiu, Xueyu,Han, Yadong,Zhuang, Xiuli,et al. Preparation of nano-hydroxyapatite/poly(L-lactide) biocomposite microspheres[J]. JOURNAL OF NANOPARTICLE RESEARCH,2007,9(5):901-908. |
| APA | Qiu, Xueyu,Han, Yadong,Zhuang, Xiuli,Chen, Xuesi,Li, Yuesheng,&Jing, Xiabin.(2007).Preparation of nano-hydroxyapatite/poly(L-lactide) biocomposite microspheres.JOURNAL OF NANOPARTICLE RESEARCH,9(5),901-908. |
| MLA | Qiu, Xueyu,et al."Preparation of nano-hydroxyapatite/poly(L-lactide) biocomposite microspheres".JOURNAL OF NANOPARTICLE RESEARCH 9.5(2007):901-908. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。