Prediction of octanol-water partition coefficients (log P) of drugs by micellar liquid chromatography simulating biomembrane
文献类型：期刊论文
| 作者 | Jia Hong-Ying; Yang Geng-Liang; Xin Pei-Yong; Chen Yi |
| 刊名 | ACTA CHIMICA SINICA
 |
| 出版日期 | 2007-04-28 |
| 卷号 | 65期号:8页码:693-698 |
| 关键词 | Micellar Liquid Chromatography Surfactant Brij 35 Octanol-water Partition Coefficient Log p |
| ISSN号 | 0567-7351 |
| 英文摘要 | Brij35 micellar liquid chromatography (MLC) was presented for prediction of the octanol-water partition coefficient (log P) of drugs by comparing the retention factors of drugs in different surfactants with log P in literature. The results showed that the retention factors of drugs in Brij35 MLC were related with log P of drugs in literature. The effect of Brij35 concentration on the retention of drugs was studied and the relationship was established between the retention factors of drugs in surfactant of different concentration and log P. This method is simple, rapid and can provide valuable reference information for hydrophobicity of drugs. |
| 语种 | 英语 |
| WOS记录号 | WOS:000246083000008 |
| 出版者 | SCIENCE CHINA PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/60527]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jia Hong-Ying |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China 2.Hebei Univ, Coll Pharm, Baoding 071002, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jia Hong-Ying,Yang Geng-Liang,Xin Pei-Yong,et al. Prediction of octanol-water partition coefficients (log P) of drugs by micellar liquid chromatography simulating biomembrane[J]. ACTA CHIMICA SINICA,2007,65(8):693-698. |
| APA | Jia Hong-Ying,Yang Geng-Liang,Xin Pei-Yong,&Chen Yi.(2007).Prediction of octanol-water partition coefficients (log P) of drugs by micellar liquid chromatography simulating biomembrane.ACTA CHIMICA SINICA,65(8),693-698. |
| MLA | Jia Hong-Ying,et al."Prediction of octanol-water partition coefficients (log P) of drugs by micellar liquid chromatography simulating biomembrane".ACTA CHIMICA SINICA 65.8(2007):693-698. |
入库方式： OAI收割
来源：化学研究所
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