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Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration
文献类型：期刊论文
| 作者 | Wang, Jiangxue; Zhou, Guoqiang; Chen, Chunying; Yu, Hongwei; Wang, Tiancheng; Ma, Yongmei; Jia, Guang; Gao, Yuxi; Li, Bai; Sun, Jin |
| 刊名 | TOXICOLOGY LETTERS
 |
| 出版日期 | 2007-01-30 |
| 卷号 | 168期号:2页码:176-185 |
| 关键词 | Acute Toxicity Fixed Dose Procedure Titanium Dioxide Nanoparticles Mice |
| ISSN号 | 0378-4274 |
| DOI | 10.1016/j.toxlet.2006.12.001 |
| 英文摘要 | In order to evaluate the toxicity of TiO2 particles, the acute toxicity of nano-sized TiO2 particles (25 and 80 nm) on adult mice was investigated compared with fine TiO2 particles (155 nm). Due to the low toxicity, a fixed large dose of 5 g/kg body weight of TiO2 suspensions was administrated by a single oral gavage according to the OECD procedure. In 2 weeks, TiO2 particles showed no obvious acute toxicity. However, the female mice showed high coefficients of liver in the nano-sized (25 and 80 nm) groups. The changes of serum biochemical parameters (ALT/AST, LDH) and pathology (hydropic degeneration around the central vein and the spotty necrosis of hepatocytes) of liver indicated that the hepatic injury was induced after exposure to mass different-sized TiO2 particles. In addition, the nephrotoxicity like increased BUN level and pathology change of kidneys was also observed in the experimental groups. The significant change of serum LDH and alpha-HBDH in 25 and 80 nm groups showed the myocardial damage compared with the control group. However, there are no abnormal pathology changes in the heart, lung, testicle (ovary), and spleen tissues. Biodistribution experiment showed that TiO2 mainly retained in the liver, spleen, kidneys, and lung tissues, which indicated that TiO2 particles could be transported to other tissues and organs after uptake by gastrointestinal tract. (c) 2006 Elsevier Ireland Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000244059300010 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/60873]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen, Chunying |
| 作者单位 | 1.Chinese Acad Sci, Lab Bioenvironm Effects Nanomat & Nanosafety, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Natl Ctr NanoSci & Technol, Key Lab Nucl Analyt Tech, Beijing 100080, Peoples R China 3.Chinese Acad Sci, Inst High Energy Phys, Beijing 100080, Peoples R China 4.Grad Univ, Chinese Acad Sci, Beijing 100049, Peoples R China 5.Peking Univ, Hosp Peking 3, Dept Clin Lab Med, Beijing 100083, Peoples R China 6.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China 7.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100083, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jiangxue,Zhou, Guoqiang,Chen, Chunying,et al. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration[J]. TOXICOLOGY LETTERS,2007,168(2):176-185. |
| APA | Wang, Jiangxue.,Zhou, Guoqiang.,Chen, Chunying.,Yu, Hongwei.,Wang, Tiancheng.,...&Chai, Zhifang.(2007).Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration.TOXICOLOGY LETTERS,168(2),176-185. |
| MLA | Wang, Jiangxue,et al."Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration".TOXICOLOGY LETTERS 168.2(2007):176-185. |
入库方式： OAI收割
来源：化学研究所
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