Triblock poly(lactic acid)-b-poly(ethylene glycol)-b-poly(lactic acid)/paclitaxel conjugates: Synthesis, micellization, and cytotoxicity
文献类型：期刊论文
| 作者 | Xie, Zhigang; Lu, Tiancheng; Chen, Xuesi; Lu, Changhai; Zheng, Yonghui; Jing, Xiabin |
| 刊名 | JOURNAL OF APPLIED POLYMER SCIENCE
 |
| 出版日期 | 2007-08-15 |
| 卷号 | 105期号:4页码:2271-2279 |
| 关键词 | Polyesters Ring-opening Polymerization Synthesis |
| ISSN号 | 0021-8995 |
| DOI | 10.1002/app.26236 |
| 英文摘要 | A triblock poly(lactic acid)-b-poly(ethylene glycol)-b-poly(lactic acid) (PLA-PEG-PLA)/paclitaxel (PTX) conjugate was synthesized by the reaction of carboxyl-terminated copolymer PLA-PEG-PLA with PTX in the presence of dicyclohexylcarbodiimide and dimethylaminopyridine. Carboxyl-terminated copolymer PLA-PEG-PLA was prepared by the reaction of the hydroxyl end groups in copolymer PLA-PEG-PLA with succinic anhydride. Its structure was confirmed by NMR and gel permeation chromatography. The PLA-PEG-PLA/PTX conjugates could self-assemble into micelles in aqueous solutions with a low critical micelle concentration. Dynamic light scattering and environmental scanning electron microscopy analyses of the PLA-PEG-PLA/PTX micelles revealed their spherical structure and size of 220 nm. The antitumor activity of the conjugate against woman Hela cancer cells, evaluated by the 3-(4,5-dimethylthiazol2-yl)-2,5-diphenyl tetrazolium bromide method, showed that the conjugates had an antitumor activity similar to that of pure PTX. The obtained PLA-PEG-PLA/PTX conjugates are expected to be used in clinical practice. (c) 2007 Wiley Periodicals, Inc. |
| 语种 | 英语 |
| WOS记录号 | WOS:000247576600069 |
| 出版者 | JOHN WILEY & SONS INC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/60881]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Zhigang,Lu, Tiancheng,Chen, Xuesi,et al. Triblock poly(lactic acid)-b-poly(ethylene glycol)-b-poly(lactic acid)/paclitaxel conjugates: Synthesis, micellization, and cytotoxicity[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2007,105(4):2271-2279. |
| APA | Xie, Zhigang,Lu, Tiancheng,Chen, Xuesi,Lu, Changhai,Zheng, Yonghui,&Jing, Xiabin.(2007).Triblock poly(lactic acid)-b-poly(ethylene glycol)-b-poly(lactic acid)/paclitaxel conjugates: Synthesis, micellization, and cytotoxicity.JOURNAL OF APPLIED POLYMER SCIENCE,105(4),2271-2279. |
| MLA | Xie, Zhigang,et al."Triblock poly(lactic acid)-b-poly(ethylene glycol)-b-poly(lactic acid)/paclitaxel conjugates: Synthesis, micellization, and cytotoxicity".JOURNAL OF APPLIED POLYMER SCIENCE 105.4(2007):2271-2279. |
入库方式： OAI收割
来源：化学研究所
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