Synthesis, characterization and biological activity of diorganotin(IV) complexes of N-(3,5-dibromo-salicylidene)-alpha-amino acid
文献类型：期刊论文
| 作者 | Tian Lai-Jin; Sun Yu-Xi; Zheng Xiao-Liang; Liu Xi-Jie; Yu You; Liu Xue-Li; Qian Bo-Chu |
| 刊名 | CHINESE JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2007-03-01 |
| 卷号 | 25期号:3页码:312-318 |
| 关键词 | Organotin Complex Alpha-amino Acid Antitumour Activity X-ray Crystal Structure |
| ISSN号 | 1001-604X |
| 英文摘要 | The diorganotin(IV) complexes of N-(3,5-dibromosalicylidene)-alpha-amino acid, R-2'Sn(2-O-3,5-Br2C6H2CH = NCHRCOO)(where R = H, Me, i-Pr, Bz; R' = n-Bu, Cy), were synthesized by the reactions of diorganotin dichlorides with in situ formed potassium salt of N-(3,5-dibromosalicylidene)-a-amino acid and characterized by elemental analysis, IR and NMR (H-1, C-13 and Sn-119) spectra. The crystal structures of n-Bu2Sn(2-O-3,5-Br(2)C(6)H2CH = NCHRCOO)(R = i-Pr, Bz) and Cy2Sn(2-O-3,5-Br2C6H2CH = NCHRCOO)(R = Me, Bz) were determined by X-ray single crystal diffraction and showed that the tin atoms are in a distorted trigonal bipyramidal geometry to form five- and six-membered chelate rings with the tridentate ligand. Bioassay results indicated that the compounds possess better in vitro antitumour activity against three human tumour cell lines, HeLa, CoLo205 and MCF-7, than cis-platin and moderate anti-bacterial activity against two bacteria, E. coli and S. aureus. |
| 语种 | 英语 |
| WOS记录号 | WOS:000244805800010 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/60893]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Tian Lai-Jin |
| 作者单位 | 1.Qufu Normal Univ, Dept Chem, Shandong 273165, Peoples R China 2.Zhejiang Acad Med Sci, Inst Mat Med, Hangzhou 310013, Zhejiang, Peoples R China 3.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian Lai-Jin,Sun Yu-Xi,Zheng Xiao-Liang,et al. Synthesis, characterization and biological activity of diorganotin(IV) complexes of N-(3,5-dibromo-salicylidene)-alpha-amino acid[J]. CHINESE JOURNAL OF CHEMISTRY,2007,25(3):312-318. |
| APA | Tian Lai-Jin.,Sun Yu-Xi.,Zheng Xiao-Liang.,Liu Xi-Jie.,Yu You.,...&Qian Bo-Chu.(2007).Synthesis, characterization and biological activity of diorganotin(IV) complexes of N-(3,5-dibromo-salicylidene)-alpha-amino acid.CHINESE JOURNAL OF CHEMISTRY,25(3),312-318. |
| MLA | Tian Lai-Jin,et al."Synthesis, characterization and biological activity of diorganotin(IV) complexes of N-(3,5-dibromo-salicylidene)-alpha-amino acid".CHINESE JOURNAL OF CHEMISTRY 25.3(2007):312-318. |
入库方式： OAI收割
来源：化学研究所
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