Asymmetric lewis acid catalyzed addition of isocyanides to aldehydes synthesis of 5-amino-2-(1-hydroxyalkyl)oxazoles
文献类型：期刊论文
| 作者 | Wang, Shixin; Wang, Mei-Xiang; Wang, De-Xian; Zhu, Jieping |
| 刊名 | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2007-08-01 |
| 期号 | 24页码:4076-4080 |
| 关键词 | Asymmetric Synthesis Chiral Catalyst Isocyanide Alpha-isocyanoacetaniide Multicomponent Reaction Oxazole Passerini Reaction |
| ISSN号 | 1434-193X |
| DOI | 10.1002/ejoc.200700340 |
| 英文摘要 | Stannous chloride efficiently catalyzes condensations between alpha-isocyanoacetamides (1) and a variety of aldehydes to afford the corresponding 5-amino-2-(1-hydroxyalkyl-)oxazoles (3) in good to excellent yields. The [Sn-(R)-Ph-PyBox](OTf)(2)-catalyzed reaction between la and 2-(benzyloxy)acetaldehyde (2g) shows an isoinversion effect, with the maximum enantiomeric excess of oxazole 3g (80 %) being obtained at -40 degrees C. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007). |
| 语种 | 英语 |
| WOS记录号 | WOS:000249057500013 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/61009]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Mei-Xiang |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Natl Lab Mol Sci, Biol Chem Lab, Beijing 100080, Peoples R China 2.CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France |
| 推荐引用方式 GB/T 7714 | Wang, Shixin,Wang, Mei-Xiang,Wang, De-Xian,et al. Asymmetric lewis acid catalyzed addition of isocyanides to aldehydes synthesis of 5-amino-2-(1-hydroxyalkyl)oxazoles[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2007(24):4076-4080. |
| APA | Wang, Shixin,Wang, Mei-Xiang,Wang, De-Xian,&Zhu, Jieping.(2007).Asymmetric lewis acid catalyzed addition of isocyanides to aldehydes synthesis of 5-amino-2-(1-hydroxyalkyl)oxazoles.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(24),4076-4080. |
| MLA | Wang, Shixin,et al."Asymmetric lewis acid catalyzed addition of isocyanides to aldehydes synthesis of 5-amino-2-(1-hydroxyalkyl)oxazoles".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .24(2007):4076-4080. |
入库方式： OAI收割
来源：化学研究所
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