Sugars-grafted aliphatic biodegradable poly(L-lactide-co-carbonate)s by click reaction and their specific interaction with lectin molecules
文献类型：期刊论文
| 作者 | Lu, Changhai; Shi, Quan; Chen, Xuesi; Lu, Tiancheng; Xie, Zhigang; Hu, Xiuli; Ma, Jia; Jing, Xiabin |
| 刊名 | JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
 |
| 出版日期 | 2007-08-01 |
| 卷号 | 45期号:15页码:3204-3217 |
| 关键词 | Biodegradable Polyester Click Reaction Sugar Lectin Specific Interaction |
| ISSN号 | 0887-624X |
| DOI | 10.1002/pola.22070 |
| 英文摘要 | A novel biodegradable aliphatic poly(L-lactide-co-carbonate) bearing pendant acetylene groups was successfully prepared by ring-opening copolymerization of L-lactide (LA) with 5-methyl-5-propargyloxycarbonyl-1,3-dioxan-2-one (PC) in the presence of benzyl alcohol as initiator with ZnEt2 as catalyst in bulk at 100 degrees C and subsequently used for grafting 2-azidoethyl beta-D-glucopyranoside and 2-azidoethyl beta-lactoside by the typical "click reaction," that is Cu(I)-catalyzed cycloaddition of azide and alkyne. The density of acetylene groups in the copolymer can be tailored by the molar ratio of PC to LA during the copolymerization. The aliphatic copolymers grafted with sugars showed low cytotoxicity to L929 cells, improved hydrophilic properties and specific recognition and binding ability with lectins, that is Concanavalin A (Con A) and Ricinus communis agglutinin (RCA). Therefore, this kind of sugar-grafted copolymer could be a good candidate in variety of biomedical applications. (c) 2007 Wiley Periodicals, Inc. |
| 语种 | 英语 |
| WOS记录号 | WOS:000248021700006 |
| 出版者 | JOHN WILEY & SONS INC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/61243]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Changhai,Shi, Quan,Chen, Xuesi,et al. Sugars-grafted aliphatic biodegradable poly(L-lactide-co-carbonate)s by click reaction and their specific interaction with lectin molecules[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,2007,45(15):3204-3217. |
| APA | Lu, Changhai.,Shi, Quan.,Chen, Xuesi.,Lu, Tiancheng.,Xie, Zhigang.,...&Jing, Xiabin.(2007).Sugars-grafted aliphatic biodegradable poly(L-lactide-co-carbonate)s by click reaction and their specific interaction with lectin molecules.JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,45(15),3204-3217. |
| MLA | Lu, Changhai,et al."Sugars-grafted aliphatic biodegradable poly(L-lactide-co-carbonate)s by click reaction and their specific interaction with lectin molecules".JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY 45.15(2007):3204-3217. |
入库方式： OAI收割
来源：化学研究所
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