Selective deprotection of N-Boc catalyzed by silica gel
文献类型：期刊论文
| 作者 | Zhang Min-Jie1,2; Yuan Xiu-Hua1; Ma Li1; Zhao Jian-Ying1; Gao Lian-Xun1 |
| 刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
 |
| 出版日期 | 2007-12-10 |
| 卷号 | 28期号:12页码:2330-2332 |
| 关键词 | N-boc Deprotection Silica Gel Selective Deprotection |
| ISSN号 | 0251-0790 |
| 英文摘要 | As an important protective group of amines and amino acids, tert-butoxycarbonyl(Boc) group was extensively used in organic synthesis. Though many mild and selective reagents could be used, there is still a need for the development of a more simple and convenient method for deprotection. In this paper, a new method for the deprotection of N-Boc group with silica gel in refluxing toluene was reported. The reactions were mostly achieved in 5 h with high yields (75% - 98%). N-Boc protected indoline and benzylamine, which are not deprotected with other mild method, could be deprotected with our method in good yields(89% and 95%, respectively). Additionally the deprotection of other carbamates such as Cbz, Fmoc and ethyl carbamate wasn't observed under same conditions. |
| 语种 | 英语 |
| WOS记录号 | WOS:000251953400023 |
| 出版者 | HIGHER EDUCATION PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/61247]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Gao Lian-Xun |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang Min-Jie,Yuan Xiu-Hua,Ma Li,et al. Selective deprotection of N-Boc catalyzed by silica gel[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2007,28(12):2330-2332. |
| APA | Zhang Min-Jie,Yuan Xiu-Hua,Ma Li,Zhao Jian-Ying,&Gao Lian-Xun.(2007).Selective deprotection of N-Boc catalyzed by silica gel.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,28(12),2330-2332. |
| MLA | Zhang Min-Jie,et al."Selective deprotection of N-Boc catalyzed by silica gel".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 28.12(2007):2330-2332. |
入库方式： OAI收割
来源：化学研究所
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