Immuno-stimulating properties of diosgenyl saponins isolated from Paris polyphylla
文献类型：期刊论文
| 作者 | Zhang, Xiu-feng; Cui, Yan; Huang, Jia-jun; Zhang, Ya-zhou; Nie, Zhou; Wang, Lan-fen; Yan, Bao-zhen; Tang, Ya-lin; Liu, Yang |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2007-05-01 |
| 卷号 | 17期号:9页码:2408-2413 |
| 关键词 | Paris Polyphylla Diosgenyl Saponins Phagocytosis Respiratory Burst Superoxide Anion Nitric Oxide |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2007.02.039 |
| 英文摘要 | The effects of three diosgenyl saponins isolated from Paris polyphylla on the immuno -stimulating activity in relation to phagocytosis, respiratory burst, and nitric oxide production in mouse macrophage cells RAW 264.7 have been investigated. Our results showed that all three diosgenyl saponins significantly enhanced phagocytic activity that increased with the concentration of saponins to reach a maximum, and then tended to decrease with higher concentrations. Saponins with sugar moiety directly induced respiratory burst response in RAW 264.7 cells that increased with the concentrations and reached a maximum, then decreased with higher concentrations after 2-h incubations, however, diosgenin had no PMA-triggered respiratory burst response. Treatment of RAW 264.7 cells with saponins with sugar moiety for 24-h caused a significant increase in the production of nitric oxide, while diosgenin had no effect at all. Consequently, relationship between molecular structures of three diosgenyl saponins and their immunomodulatory activities was discussed, and a possible mechanism of immuno- stimulating function of diosgenyl saponins was accordingly explored. (C) 2007 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000246087900003 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/61265]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Yang |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, State Key Lab SCUSS, Beijing 100080, Peoples R China 2.Shenyang Pharmaceut Univ, China Sch Pharm, Shenyang 110016, Peoples R China 3.Beijing Univ Chem Technol, Fac Sci, Beijing 100029, Peoples R China 4.Chongqing Univ Med Sci, Coll Basic Med, Chongqing 400016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiu-feng,Cui, Yan,Huang, Jia-jun,et al. Immuno-stimulating properties of diosgenyl saponins isolated from Paris polyphylla[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2007,17(9):2408-2413. |
| APA | Zhang, Xiu-feng.,Cui, Yan.,Huang, Jia-jun.,Zhang, Ya-zhou.,Nie, Zhou.,...&Liu, Yang.(2007).Immuno-stimulating properties of diosgenyl saponins isolated from Paris polyphylla.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,17(9),2408-2413. |
| MLA | Zhang, Xiu-feng,et al."Immuno-stimulating properties of diosgenyl saponins isolated from Paris polyphylla".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17.9(2007):2408-2413. |
入库方式： OAI收割
来源：化学研究所
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