QRAR models for cardiovascular system drugs using biopartitioning micellar chromatography
文献类型：期刊论文
| 作者 | Wang, Sumin; Yang, Gengliang; Zhang, Hua; Liu, Haiyan; Li, Zhiwei |
| 刊名 | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
 |
| 出版日期 | 2007-02-01 |
| 卷号 | 846期号:1-2页码:329-333 |
| 关键词 | Biopartitioning Micellar Chromatography (Bmc) Cardiovascular System Drugs Qrar Model |
| ISSN号 | 1570-0232 |
| DOI | 10.1016/j.jchromb.2006.08.027 |
| 英文摘要 | The capability of biopartitioning micellar chromatography (BMC) to describe and estimate pharmacological parameters of cardiovascular system drugs has been studied. The retention of cardiovascular system drugs was studied using different pH of Brij-35 as micellar mobile phase in modified C-18 stationary phase. Quantitative retention-activity relationships (QRAR) in BMC were investigated for these compounds. An adequate correlation between the retention factors (log k) and the toxicity (LD50) of cardiovascular system drugs was obtained. (c) 2006 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000244281100044 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/61529]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yang, Gengliang |
| 作者单位 | 1.Hebei Univ, Coll Pharm, Baoding 071002, Peoples R China 2.Hebei Med Univ, Dept Pharmacol, Shijiazhuang 050017, Peoples R China 3.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China 4.N China Pharmaceut Corp, New Drug Res & Dev Ctr, Hebei 050015, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Sumin,Yang, Gengliang,Zhang, Hua,et al. QRAR models for cardiovascular system drugs using biopartitioning micellar chromatography[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2007,846(1-2):329-333. |
| APA | Wang, Sumin,Yang, Gengliang,Zhang, Hua,Liu, Haiyan,&Li, Zhiwei.(2007).QRAR models for cardiovascular system drugs using biopartitioning micellar chromatography.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,846(1-2),329-333. |
| MLA | Wang, Sumin,et al."QRAR models for cardiovascular system drugs using biopartitioning micellar chromatography".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 846.1-2(2007):329-333. |
入库方式： OAI收割
来源：化学研究所
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