Solubilization of phosphatidylcholine vesicles by hydrophobically modified Poly(acrylamide)-co-(Acrylic acid): Effects of acrylic acid fraction and polymer concentration
文献类型：期刊论文
| 作者 | Fan, Yanru; Han, Yuchun; Wang, Yilin |
| 刊名 | JOURNAL OF PHYSICAL CHEMISTRY B
 |
| 出版日期 | 2007-08-30 |
| 卷号 | 111期号:34页码:10123-10129 |
| ISSN号 | 1520-6106 |
| DOI | 10.1021/jp0735637 |
| 英文摘要 | The interaction of hydrophobically modified copolymers of acrylamide and acrylic acid, designated as PAM-C12-AA (X%) (X% indicates the percentage of acrylic acid unit and X = 5, 10, 20), with dimyristoylphosphatidylcholine (DMPC) vesicles has been studied. Complementary techniques including isothermal titration microcalorimetry (ITC), differential scanning calorimetry (DSC), turbidity measurement, calcein leakage measurement, dynamic light scattering (DLS), and transmission electron microscopy (TEM) were used to get comprehensive information. The results show that PAM-C12-AA leads to solubilization of DMPC vesicles. There is a critical concentration (C-s) for PAM-C12-AA to induce obvious vesicle disruption. This concentration is very close to the critical aggregation concentration (CAC) for the polymer self-aggregation. The C-s values are found to be similar for the three polymers. However, the disruption of DMPC vesicles induced by the polymers increases to a greater degree at higher AA fraction, owing to the increasing strength of interaction between the polymer and the lipid bilayer. |
| 语种 | 英语 |
| WOS记录号 | WOS:000248929900010 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/61541]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Yilin |
| 作者单位 | Chinese Acad Sci, Inst Chem, Key Lab Colloid & Interface Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Yanru,Han, Yuchun,Wang, Yilin. Solubilization of phosphatidylcholine vesicles by hydrophobically modified Poly(acrylamide)-co-(Acrylic acid): Effects of acrylic acid fraction and polymer concentration[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2007,111(34):10123-10129. |
| APA | Fan, Yanru,Han, Yuchun,&Wang, Yilin.(2007).Solubilization of phosphatidylcholine vesicles by hydrophobically modified Poly(acrylamide)-co-(Acrylic acid): Effects of acrylic acid fraction and polymer concentration.JOURNAL OF PHYSICAL CHEMISTRY B,111(34),10123-10129. |
| MLA | Fan, Yanru,et al."Solubilization of phosphatidylcholine vesicles by hydrophobically modified Poly(acrylamide)-co-(Acrylic acid): Effects of acrylic acid fraction and polymer concentration".JOURNAL OF PHYSICAL CHEMISTRY B 111.34(2007):10123-10129. |
入库方式： OAI收割
来源：化学研究所
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