Programmable delivery of hydrophilic drug using dually responsive hydrogel cages
文献类型：期刊论文
| 作者 | Gu, Jingxia; Xia, Fan; Wu, Yan; Qu, Xiaozhong; Yang, Zhenzhong; Jiang, Lei |
| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 2007-02-26 |
| 卷号 | 117期号:3页码:396-402 |
| 关键词 | Polymeric Hydrogel Cages Responsive Programmable Drug Delivery |
| ISSN号 | 0168-3659 |
| DOI | 10.1016/j.jconrel.2006.11.029 |
| 英文摘要 | Micro-capsules normally encapsulate therapeutic agents only inside their cavities. In this paper, we report on the synthesis of dually responsive poly(N-isopropylacrylamide) (PNiPAM)-co-acrylic acid (AA) hydrogel cages sub-micrometer in size and the use of these cages as drug carriers. The cavity structure of the cages can enhance volume phase transition compared to solid gel particles, thus favoring drug loading and release. TEM images and FT-IR spectra confirmed that the model drug isoniazid (INH) is located in two regions: within the shell and inside the cavity of the cages. The drugs residing in the shell can form hydrogen bonds with the cage matrix, while the drugs in the cavity are interaction free with the carrier. This difference from the residency of drugs exploited to a structure induced drug release which was programmable controlled by external pH and temperature. In vitro drug release studies showed that in a neutral medium (pH = 7.4), major drugs were preserved within the shell, while in an acidic medium (pH = 1.2), nearly all of the drugs were released due to the dissociation of hydrogen bonds. (c) 2006 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000244928100012 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/61729]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Qu, Xiaozhong |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100080, Peoples R China 2.Natl Ctr Nanosci & Technol, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gu, Jingxia,Xia, Fan,Wu, Yan,et al. Programmable delivery of hydrophilic drug using dually responsive hydrogel cages[J]. JOURNAL OF CONTROLLED RELEASE,2007,117(3):396-402. |
| APA | Gu, Jingxia,Xia, Fan,Wu, Yan,Qu, Xiaozhong,Yang, Zhenzhong,&Jiang, Lei.(2007).Programmable delivery of hydrophilic drug using dually responsive hydrogel cages.JOURNAL OF CONTROLLED RELEASE,117(3),396-402. |
| MLA | Gu, Jingxia,et al."Programmable delivery of hydrophilic drug using dually responsive hydrogel cages".JOURNAL OF CONTROLLED RELEASE 117.3(2007):396-402. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。