Tunable non-equilibrium gating of flexible DNA nanochannels in response to transport flux
文献类型：期刊论文
| 作者 | Mao, Youdong; Chang, Song; Yang, Shaoxuan; Ouyang, Qi; Jiang, Lei |
| 刊名 | NATURE NANOTECHNOLOGY
 |
| 出版日期 | 2007-06-01 |
| 卷号 | 2期号:6页码:366-371 |
| ISSN号 | 1748-3387 |
| DOI | 10.1038/nnano.2007.148 |
| 英文摘要 | Biological nanochannels made from proteins play a central role in cellular signalling(1-9). The rapid emergence of DNA nanotechnology in recent years(10-13) has opened up the possibility of making similar nanochannels from DNA. Building on previous work on switchable DNA nanocompartment(14,15), We have constructed complex DNA nanosystems to investigate the gating behaviour of these nanochannels. Here we show that DNA nanochannels can be gated by stress exerted by permeating solute particles at non-equilibrium states due to the high flexibility of the nanochannels. This novel gating mechanism results in tunable ratchet-like transport of solute particles through the nanochannels. A simple model that couples non-equilibrium channel gating with transport flux can quantitatively explain a number of the phenomena we observe. With only one set of model parameters, we can reproduce diverse gating behaviours, modulated by an inherent gating threshold. This work could lead to the development of new devices based on DNA nanochannels. |
| 语种 | 英语 |
| WOS记录号 | WOS:000247379800015 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/61795]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Mao, Youdong |
| 作者单位 | 1.Peking Univ, Sch Phys, Beijing 100871, Peoples R China 2.Peking Univ, Ctr Theoret Biol, Beijing 100871, Peoples R China 3.Natl Ctr Nanosci & Technol, Beijing 100080, Peoples R China 4.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mao, Youdong,Chang, Song,Yang, Shaoxuan,et al. Tunable non-equilibrium gating of flexible DNA nanochannels in response to transport flux[J]. NATURE NANOTECHNOLOGY,2007,2(6):366-371. |
| APA | Mao, Youdong,Chang, Song,Yang, Shaoxuan,Ouyang, Qi,&Jiang, Lei.(2007).Tunable non-equilibrium gating of flexible DNA nanochannels in response to transport flux.NATURE NANOTECHNOLOGY,2(6),366-371. |
| MLA | Mao, Youdong,et al."Tunable non-equilibrium gating of flexible DNA nanochannels in response to transport flux".NATURE NANOTECHNOLOGY 2.6(2007):366-371. |
入库方式： OAI收割
来源：化学研究所
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