A highly selective fluorescence turn-on sensor for Cysteine/Homocysteine and its application in bioimaging
文献类型：期刊论文
| 作者 | Zhang, Meng; Yu, Mengxiao; Li, Fuyou; Zhu, Minwei; Li, Manyu; Gao, Yanhong; Li, Lei; Liu, Zhiqiang; Zhang, Jianping; Zhang, Dengqing |
| 刊名 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| 出版日期 | 2007-08-29 |
| 卷号 | 129期号:34页码:10322-+ |
| ISSN号 | 0002-7863 |
| DOI | 10.1021/ja073140i |
| 英文摘要 | We demonstrated a highly electron-deficient system 1 as a turn-on fluorescence sensor for intracellular imaging of Cys/Hcy in biological samples. On the basis of the specific nucleophilic ability of thiols of Cys and Hcy, 1 exhibited high selectivity and sensitivity for Cys/Hcy over other amino acids and thiol biomolecules. This probe is the first Cys/Hcy sensor with excitation in the visible region and turn-on (75-fold) fluorescence emission and also gives a significant increase in two-photon excited fluorescence for sensing Cys/Hcy. Moreover, confocal laser scanning microscopy and two-photon laser scanning microscopy experiments further established that 1 can be used for sensing Cys/Hcy within biological samples. |
| 语种 | 英语 |
| WOS记录号 | WOS:000249035200012 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/61903]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Fuyou |
| 作者单位 | 1.Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China 2.Fudan Univ, Adv Mat Lab, Shanghai 200433, Peoples R China 3.Fudan Univ, Hosp Obstet & Gynecol, Shanghai 200433, Peoples R China 4.Chinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100080, Peoples R China 5.Shanghai Jiao Tong Univ, Hosp Xinhua, Sch Med, Shanghai 200092, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Meng,Yu, Mengxiao,Li, Fuyou,et al. A highly selective fluorescence turn-on sensor for Cysteine/Homocysteine and its application in bioimaging[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2007,129(34):10322-+. |
| APA | Zhang, Meng.,Yu, Mengxiao.,Li, Fuyou.,Zhu, Minwei.,Li, Manyu.,...&Huang, Chunhui.(2007).A highly selective fluorescence turn-on sensor for Cysteine/Homocysteine and its application in bioimaging.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,129(34),10322-+. |
| MLA | Zhang, Meng,et al."A highly selective fluorescence turn-on sensor for Cysteine/Homocysteine and its application in bioimaging".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 129.34(2007):10322-+. |
入库方式： OAI收割
来源：化学研究所
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