Preparation and drug release Behaviors of 5-fluorouracil loaded poly(glycolide-co-lactide-co-caprolactone) nanoparticles
文献类型：期刊论文
| 作者 | Zhang, Hanwei; Bei, Jianzhong; Wang, Shenguo |
| 刊名 | JOURNAL OF APPLIED POLYMER SCIENCE
 |
| 出版日期 | 2007-12-15 |
| 卷号 | 106期号:6页码:3757-3767 |
| 关键词 | Nanotechnology 5-fluorouracil (5-fu) Drug Delivery System Polyesters Biodegradation |
| ISSN号 | 0021-8995 |
| DOI | 10.1002/app.26212 |
| 英文摘要 | 5-Fluorouracil (5-Fu) loaded poly(glycolideco-lactide-co-caprolactone) (PGLC) nanoparticles were prepared by modified spontaneous emulsification solvent diffusion method (modified-SESD method) and characterized by dynamic light scattering, scanning electron microscopy and H NMR determination. It was found that the obtained nanoparticles showed near spherical shape and was controllable with the radius range of 30-100 nm. Compared with the nanoparticles prepared by polylactide and poly (lactide-co-glycolide) (PLGA) under the similar preparation condition, yield of PGLC nanoparticles was the highest, which reached to about 100%. On the other hand, drug entrapment efficiency of PGLC nanoparticles was also higher than that of PLGA and PLLA nanoparticles. 5-Fu release behavior of PGLC nanoparticles in vitro showed that 5-Fu release of PGLC nanoparticles showed a near zero-order release profile, and 5-Fu release rate of PGLC nanoparticles was faster than that of PLLA and PLGA nanoparticles. According to degradation behavior of PGLC nanoparticles, it could be proposed that the kinetic of degradation controlled release played an important role in the release process of PGLC nanoparticles. It revealed that the PGLC nanoparticles could be a promising drug carrier. |
| 语种 | 英语 |
| WOS记录号 | WOS:000250607200026 |
| 出版者 | JOHN WILEY & SONS INC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/62205]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Shenguo |
| 作者单位 | Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, BNLMS, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Hanwei,Bei, Jianzhong,Wang, Shenguo. Preparation and drug release Behaviors of 5-fluorouracil loaded poly(glycolide-co-lactide-co-caprolactone) nanoparticles[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2007,106(6):3757-3767. |
| APA | Zhang, Hanwei,Bei, Jianzhong,&Wang, Shenguo.(2007).Preparation and drug release Behaviors of 5-fluorouracil loaded poly(glycolide-co-lactide-co-caprolactone) nanoparticles.JOURNAL OF APPLIED POLYMER SCIENCE,106(6),3757-3767. |
| MLA | Zhang, Hanwei,et al."Preparation and drug release Behaviors of 5-fluorouracil loaded poly(glycolide-co-lactide-co-caprolactone) nanoparticles".JOURNAL OF APPLIED POLYMER SCIENCE 106.6(2007):3757-3767. |
入库方式： OAI收割
来源：化学研究所
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