Synthesis and characterization of electroactive and biodegradable ABA block copolymer of polylactide and aniline pentamer
文献类型：期刊论文
| 作者 | Huang, Lihong; Hu, Jun; Lang, Le; Wang, Xin; Zhang, Peibiao; Jing, Xiabin; Wang, Xianhong; Chen, Xuesi; Lelkes, Peter I.; MacDiarmid, Alan G. |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2007-04-01 |
| 卷号 | 28期号:10页码:1741-1751 |
| 关键词 | Electroactive Biodegradable Polylactide Aniline Pentamer Biocompatibility |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2006.12.007 |
| 英文摘要 | A triblock copolymer PLA-b-AP-b-PLA (PAP) of polylactide (PLA) and aniline pentamer (AP) with the unique properties of being both electroactive and biodegradable is synthesized by coupling an electroactive carboxyl-capped AP with two biodegradable bihydroxyl-capped PLAs via a condensation reaction. Three different molecule weight PAP copolymers are prepared. The PAP copolymers exhibit excellent electroactivity similar to the AP and polyaniline, which may stimulate cell proliferation and differentiation. The electrical conductivity of the PAP2 copolymer film (similar to 5 x 10(-6) S/cm) is in the semiconducting region. Transmission electron microscopic results suggest that there is microphase separation of the two block segments in the copolymer, which might contribute to the observed conductivity. The biodegradation and biocompatibility experiments in vitro prove the copolymer is biodegradable and biocompatible. Moreover, these new block copolymer shows good solubility in common organic solvents, leading to the system with excellent processibility. These biodegradable PAP copolymers with electroactive function thus possess the properties that would be potentially used as scaffold materials for neuronal or cardiovascular tissue engineering. (c) 2006 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000244436000001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/62397]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen, Xuesi |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Drexel Univ, Dept Chem, Philadelphia, PA 19104 USA 4.Drexel Univ, Sch Biomed Engn, Philadelphia, PA 19104 USA 5.Univ Penn, Dept Chem, Philadelphia, PA 19104 USA |
| 推荐引用方式 GB/T 7714 | Huang, Lihong,Hu, Jun,Lang, Le,et al. Synthesis and characterization of electroactive and biodegradable ABA block copolymer of polylactide and aniline pentamer[J]. BIOMATERIALS,2007,28(10):1741-1751. |
| APA | Huang, Lihong.,Hu, Jun.,Lang, Le.,Wang, Xin.,Zhang, Peibiao.,...&Wei, Yen.(2007).Synthesis and characterization of electroactive and biodegradable ABA block copolymer of polylactide and aniline pentamer.BIOMATERIALS,28(10),1741-1751. |
| MLA | Huang, Lihong,et al."Synthesis and characterization of electroactive and biodegradable ABA block copolymer of polylactide and aniline pentamer".BIOMATERIALS 28.10(2007):1741-1751. |
入库方式： OAI收割
来源：化学研究所
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