The effect of oxygen plasma pretreatment and incubation in modified simulated body fluids on the formation of bone-like apatite on poly(lactide-co-glycolide) (70/30)
文献类型：期刊论文
| 作者 | Qu, Xue; Cui, Wenjin; Yang, Fei; Min, Changchun; Shen, Hong; Bei, Jianzhong; Wang, Shenguo |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2007 |
| 卷号 | 28期号:1页码:9-18 |
| 关键词 | Apatite Simulated Body Fluid Oxygen-plasma Poly(Lactide-co-glycolide) Surface Topography Surface Chemistry |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2006.08.024 |
| 英文摘要 | In this study, biodegradable poly(lactide-co-glycolide) (PLGA) (70/30) films and scaffolds were first treated with oxygen plasma and then incubated in a modified simulated body fluid 1.5SBFO to prepare a bone-like apatite layer. The formation of the apatite and its influence on osteoblast-like cells growth were investigated. It was found that the bone-like apatite formability of PLGA(70/30) was enhanced by plasma pretreatment. The changes of surface chemistry and surface topography induced by oxygen plasma treatment were both effective for apatite formation. The apatite formability increased with increasing plasma-treating time. Under a treating condition of 20W for 30 min, oxygen plasma treatment could penetrate into the inner scaffold. After 6 days incubation, the apatite formed in plasma-treated scaffold was better distributed than in untreated scaffold, and the weight and mechanical strength of the plasmatreated scaffold were both enhanced. Compared with PLGA(70/30), the apatite layer formed on oxygen plasma-treated PLGA(70/30) surface enhanced adhesion and proliferation of OCT-1 osteoblast-like cell, but had no significant effect on cell's ALP activity at day 7. A prolonged investigation is being in process to further verify the bone-like apatite effects on osteogenic differentiation. (c) 2006 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000242424900002 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/62587]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Shenguo |
| 作者单位 | Chinese Acad Sci, Inst Chem, BNLMS, State Key Lab Polymer Phys & Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qu, Xue,Cui, Wenjin,Yang, Fei,et al. The effect of oxygen plasma pretreatment and incubation in modified simulated body fluids on the formation of bone-like apatite on poly(lactide-co-glycolide) (70/30)[J]. BIOMATERIALS,2007,28(1):9-18. |
| APA | Qu, Xue.,Cui, Wenjin.,Yang, Fei.,Min, Changchun.,Shen, Hong.,...&Wang, Shenguo.(2007).The effect of oxygen plasma pretreatment and incubation in modified simulated body fluids on the formation of bone-like apatite on poly(lactide-co-glycolide) (70/30).BIOMATERIALS,28(1),9-18. |
| MLA | Qu, Xue,et al."The effect of oxygen plasma pretreatment and incubation in modified simulated body fluids on the formation of bone-like apatite on poly(lactide-co-glycolide) (70/30)".BIOMATERIALS 28.1(2007):9-18. |
入库方式： OAI收割
来源：化学研究所
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