Design and bioassay of non-peptidic inhibitors of SARS coronavirus 3C-like proteinase
文献类型：期刊论文
| 作者 | Liu Ying; Zheng Teng-Fei; Jin Feng; Zhou Lu; Liu Zhen-Ming; Wei Ping; Lai Lu-Hua |
| 刊名 | ACTA CHIMICA SINICA
 |
| 出版日期 | 2007-08-28 |
| 卷号 | 65期号:16页码:1707-1712 |
| 关键词 | Sars Coronavirus 3c-like Proteinase Virtual Screen Non-peptidic Inhibitor Bioassay |
| ISSN号 | 0567-7351 |
| 英文摘要 | Severe acute respiratory syndrome(SARS) coronavirus 3C-like proteinase is the key enzyme for the maturation of the virus and has been proposed to be a key target for structure based drug design against SARS. In this paper, based on the three-dimensional structure of SARS coronavirus 3C-like proteinase, the available chemical database (ACD) and clinical drug databases were used for virtual screening, and the candidate non-peptidic compounds were purchased or synthesized. Several human rhinovirus (HRV) 3C protease inhibitors were also synthesized. All the compounds were tested against SARS 3C-like proteinase bioassay. Two types of compounds including hydroxyzine dihydrochloride, a well known antihistamine, were found to inhibit the enzyme and SARS virus in cell cultivating; one of the isatin compounds shows significant inhibition with an IC50 of (0.76 +/- 0.02) mu mol center dot L-1 . The primary result. suggested that drugs in clinical usage can be developed for new purpose. |
| 语种 | 英语 |
| WOS记录号 | WOS:000249347100031 |
| 出版者 | SCIENCE CHINA PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/62783]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu Ying |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, State Key Lab Struct Chem Unstable & Stable Speci, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China 2.Peking Univ, Ctr Theoret Biol, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu Ying,Zheng Teng-Fei,Jin Feng,et al. Design and bioassay of non-peptidic inhibitors of SARS coronavirus 3C-like proteinase[J]. ACTA CHIMICA SINICA,2007,65(16):1707-1712. |
| APA | Liu Ying.,Zheng Teng-Fei.,Jin Feng.,Zhou Lu.,Liu Zhen-Ming.,...&Lai Lu-Hua.(2007).Design and bioassay of non-peptidic inhibitors of SARS coronavirus 3C-like proteinase.ACTA CHIMICA SINICA,65(16),1707-1712. |
| MLA | Liu Ying,et al."Design and bioassay of non-peptidic inhibitors of SARS coronavirus 3C-like proteinase".ACTA CHIMICA SINICA 65.16(2007):1707-1712. |
入库方式： OAI收割
来源：化学研究所
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