Lateral diffusion of TGF-beta type I receptor studied by single-molecule imaging
文献类型：期刊论文
| 作者 | Ma, Xinyong; Wang, Qiang; Jiang, Yaxin; Xiao, Zeyu; Fang, Xiaohong; Chen, Ye-Guang |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2007-04-27 |
| 卷号 | 356期号:1页码:67-71 |
| 关键词 | Single-molecule Fluorescence Imaging Mobility Tgf-beta 1 Tgf-beta Receptor Lipid-raft |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2007.02.080 |
| 英文摘要 | In this report, we investigated the lateral diffusion of transforming growth factor beta (TGF-beta) type I receptor (T beta RI) in living cells by imaging and tracking individual green fluorescent protein tagged T beta RI on the cell membrane. We found that when co-expressed with TGF-beta type 11 receptor (T beta RII), the mobility of T beta RI decreased significantly after TGF-beta 1 stimulation. However, in the cells that had been depleted of cholesterol with Nystatin or methyl-beta-cyclodextrin, the diffusion rate of T beta RI was not changed by TGF-beta 1 treatment. Our observations suggest that membrane lipid-rafts provide an environment that facilitates the association of T beta RI and T beta RII for cell signaling. (c) 2007 Elsevier Inc. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000245419300011 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/62929]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Fang, Xiaohong |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China 2.Tsing Hua Univ, State Key Lab Biomembrane & Membrane Biotechnol, Dept Biol Sci & Biotechnol, Beijing 100084, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Xinyong,Wang, Qiang,Jiang, Yaxin,et al. Lateral diffusion of TGF-beta type I receptor studied by single-molecule imaging[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,356(1):67-71. |
| APA | Ma, Xinyong,Wang, Qiang,Jiang, Yaxin,Xiao, Zeyu,Fang, Xiaohong,&Chen, Ye-Guang.(2007).Lateral diffusion of TGF-beta type I receptor studied by single-molecule imaging.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,356(1),67-71. |
| MLA | Ma, Xinyong,et al."Lateral diffusion of TGF-beta type I receptor studied by single-molecule imaging".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 356.1(2007):67-71. |
入库方式： OAI收割
来源：化学研究所
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