A Concise and Diversity-Oriented Approach to the Synthesis of SAG Derivatives
文献类型：期刊论文
| 作者 | Wang, Nengdong; Xiang, Jing; Ma, Zhibo; Quan, Junmin; Chen, Jiahua; Yang, Zhen1 |
| 刊名 | JOURNAL OF COMBINATORIAL CHEMISTRY
 |
| 出版日期 | 2008-11-01 |
| 卷号 | 10期号:6页码:825-834 |
| ISSN号 | 1520-4766 |
| DOI | 10.1021/cc800025n |
| 英文摘要 | An efficient and rapid solution-phase combinatorial synthesis of the SAG library was developed. The salient features for this library synthesis is the application of carbothioamide-derived palladacycle-catalyzed Suzuki coupling reactions for the parallel synthesis of a series of pyridine-based biaryl aldehydes under aerobic conditions and a direct N-alkylation of carbarnates using NaH as base in DMF in the presence of catalytic amount of water. The resultant library has been submitted to biological screening to evaluate their potential role in the regulation of Hedgehog pathway. |
| 语种 | 英语 |
| WOS记录号 | WOS:000260851400006 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/63097]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yang, Zhen |
| 作者单位 | 1.Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Beijing 100871, Peoples R China 2.Peking Univ, BNLMS, Coll Chem, State Key Lab Nat & Biomimet Drugs,Sch Pharmaceut, Beijing 100871, Peoples R China 3.Peking Univ, Lab Chem Genom, Shenzhen Grad Sch, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Nengdong,Xiang, Jing,Ma, Zhibo,et al. A Concise and Diversity-Oriented Approach to the Synthesis of SAG Derivatives[J]. JOURNAL OF COMBINATORIAL CHEMISTRY,2008,10(6):825-834. |
| APA | Wang, Nengdong,Xiang, Jing,Ma, Zhibo,Quan, Junmin,Chen, Jiahua,&Yang, Zhen.(2008).A Concise and Diversity-Oriented Approach to the Synthesis of SAG Derivatives.JOURNAL OF COMBINATORIAL CHEMISTRY,10(6),825-834. |
| MLA | Wang, Nengdong,et al."A Concise and Diversity-Oriented Approach to the Synthesis of SAG Derivatives".JOURNAL OF COMBINATORIAL CHEMISTRY 10.6(2008):825-834. |
入库方式： OAI收割
来源：化学研究所
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