Biodegradable amphiphilic block copolymers bearing protected hydroxyl groups: Synthesis and characterization
文献类型：期刊论文
| 作者 | Hu, Xiuli1,2; Liu, Shi1; Chen, Xuesi1; Mo, Guojun1,2; Xie, Zhigang1,2; Jing, Xiabin1 |
| 刊名 | BIOMACROMOLECULES
 |
| 出版日期 | 2008-02-01 |
| 卷号 | 9期号:2页码:553-560 |
| ISSN号 | 1525-7797 |
| DOI | 10.1021/bm701092j |
| 英文摘要 | A new biodegradable amphiphilic block copolymer, poly(ethylene glycol)-b-poly(L-factide-co-9-phenyl-2,4,8, 10-tetraoxaspiro[5,5]undecan-3-one) [PEG-b-P(LA-co-PTO)], was successfully prepared by ring-opening polymerization (ROP) Of L-lactide (LA) and functionalized carbonate monomer 9-phenyl-2,4,8,10-tetraozaspiro[5,5]undecan-3-one (PTO) in the presence of monohydroxyl poly(ethylene glycol) as macroinitiator using Sn(Oct)(2) as catalyst. NMR, FT-IR, and GPC studies confirmed the copolymer structure. It could self-assemble into micelles in aqueous solution with critical micelle concentration (CMC) in the magnitude of mg/L, which changed with the composition of the copolymer. After catalytic hydrogenation, copolymers with active hydroxyl groups were obtained. Adhesion and proliferation of Vero cells on the copolymer films showed that the synthesized copolymers were good biocompatible materials. In vitro degradation of the copolymer before and after deprotection was investigated in the presence of proteinase K. The free hydroxyl groups on the copolymers were capable of further modification with biotin. This new amphiphilic block copolymer has great potential for both drug encapsulation and conjugate because of its low CMC and the presence of active hydroxyl groups. |
| 语种 | 英语 |
| WOS记录号 | WOS:000253102100020 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/63135]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Xiuli,Liu, Shi,Chen, Xuesi,et al. Biodegradable amphiphilic block copolymers bearing protected hydroxyl groups: Synthesis and characterization[J]. BIOMACROMOLECULES,2008,9(2):553-560. |
| APA | Hu, Xiuli,Liu, Shi,Chen, Xuesi,Mo, Guojun,Xie, Zhigang,&Jing, Xiabin.(2008).Biodegradable amphiphilic block copolymers bearing protected hydroxyl groups: Synthesis and characterization.BIOMACROMOLECULES,9(2),553-560. |
| MLA | Hu, Xiuli,et al."Biodegradable amphiphilic block copolymers bearing protected hydroxyl groups: Synthesis and characterization".BIOMACROMOLECULES 9.2(2008):553-560. |
入库方式： OAI收割
来源：化学研究所
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