A Biodegradable Diblcok Copolymer Poly(ethylene glycol)-block-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate): Docetaxel and RGD Conjugation
文献类型：期刊论文
| 作者 | Xie, Zhigang1,2; Hu, Xiuli1,2; Chen, Xuesi1; Lu, Tiancheng1,2; Liu, Shi1; Jing, Xiabin1 |
| 刊名 | JOURNAL OF APPLIED POLYMER SCIENCE
 |
| 出版日期 | 2008-12-05 |
| 卷号 | 110期号:5页码:2961-2970 |
| 关键词 | Biodegradable Block Copolymers Docetaxel Rgd |
| ISSN号 | 0021-8995 |
| DOI | 10.1002/app.28900 |
| 英文摘要 | A diblcok copolymer monomethoxy poly (ethylene glycol)-block-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate) (MPEG-b-P(LA-co-MCC)) was obtained by copolymerization of L-lactide (LA) and 2-methyl-2-benzoxycarbonyl-propylene carbonate (MBC) and subsequent catalytic hydrogenation. The pendant carboxyl groups of the copolymer MPEG-b-P(LA-co-MCC) were conjugated with antitumor drug docetaxel and tripeptide arginine-glycine-aspartic acid (RGD), respectively. H-1-NMR spectra confirmed the structure of the copolymer MPEG-b-P(LA-co-MCC/docetaxel) and MPEG-b-P(LA-co-MCC/RGD). In vitro antitumor assay indicates that the MPEG-b-P(LA-co-MCC/docetaxel) conjugate shows high cytotoxic activity against HeLa cancer cells. Cell adhesion and spreading experiment shows that copolymer MPEG-b-P(LA-co-MCC/RGD) is of benefit to cell adherence and is a promising biodegradable material for cell and tissue engineering. (C) 2008 Wiley Periodicals, Inc. J Appl Polym Sci 110: 2961-2970,2008 |
| 语种 | 英语 |
| WOS记录号 | WOS:000260102800057 |
| 出版者 | JOHN WILEY & SONS INC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/63171]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Zhigang,Hu, Xiuli,Chen, Xuesi,et al. A Biodegradable Diblcok Copolymer Poly(ethylene glycol)-block-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate): Docetaxel and RGD Conjugation[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2008,110(5):2961-2970. |
| APA | Xie, Zhigang,Hu, Xiuli,Chen, Xuesi,Lu, Tiancheng,Liu, Shi,&Jing, Xiabin.(2008).A Biodegradable Diblcok Copolymer Poly(ethylene glycol)-block-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate): Docetaxel and RGD Conjugation.JOURNAL OF APPLIED POLYMER SCIENCE,110(5),2961-2970. |
| MLA | Xie, Zhigang,et al."A Biodegradable Diblcok Copolymer Poly(ethylene glycol)-block-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate): Docetaxel and RGD Conjugation".JOURNAL OF APPLIED POLYMER SCIENCE 110.5(2008):2961-2970. |
入库方式： OAI收割
来源：化学研究所
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