Activation and inhibition of leukotriene A(4) hydrolase aminopeptidase activity by diphenyl ether and derivatives
文献类型：期刊论文
| 作者 | Jiang, Xiaolu1; Zhou, Lu1; Wei, Dengguo1,2; Meng, Hu1; Liu, Ying1; Lai, Luhua1,2 |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2008-12-15 |
| 卷号 | 18期号:24页码:6549-6552 |
| 关键词 | Leukotriene a(4) Hydrolase/aminopeptidase Diphenyl Ether Derivatives Activators Inhibitors |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2008.10.044 |
| 英文摘要 | The synthesis and biological evaluation of a series of diphenyl ether derivatives were described. The compounds can either activate or inhibit the aminopeptidase activity of leukotriene A(4) hydrolase, while at the same time do not influence the hydrolase activity. Further enzyme kinetics and molecular modeling investigation on these novel chemical activators revealed their possible activation mechanism. These compounds can be used as probes to regulate the aminopeptidase activity of leukotriene A4 hydrolase. (C) 2008 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000261141100056 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/63243]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Ying |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100871, Peoples R China 2.Peking Univ, Ctr Theoret Biol, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Xiaolu,Zhou, Lu,Wei, Dengguo,et al. Activation and inhibition of leukotriene A(4) hydrolase aminopeptidase activity by diphenyl ether and derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2008,18(24):6549-6552. |
| APA | Jiang, Xiaolu,Zhou, Lu,Wei, Dengguo,Meng, Hu,Liu, Ying,&Lai, Luhua.(2008).Activation and inhibition of leukotriene A(4) hydrolase aminopeptidase activity by diphenyl ether and derivatives.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,18(24),6549-6552. |
| MLA | Jiang, Xiaolu,et al."Activation and inhibition of leukotriene A(4) hydrolase aminopeptidase activity by diphenyl ether and derivatives".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 18.24(2008):6549-6552. |
入库方式： OAI收割
来源：化学研究所
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