中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Efficient construction of pyrazolo[1,5-a]pyrimidine scaffold and its exploration as a new heterocyclic fluorescent platform

文献类型:期刊论文

作者Wu, Yan-Chao1,2; Li, Hui-Jing1; Liu, Li1; Wang, Dong1; Yang, Hua-Zheng2; Chen, Yong-Jun1
刊名JOURNAL OF FLUORESCENCE
出版日期2008-03-01
卷号18期号:2页码:357-363
关键词Fluorophore Heterocycle Fluorescence Pyrazolo[1 5-a]Pyrimidine
ISSN号1053-0509
DOI10.1007/s10895-007-0275-0
英文摘要An efficient, fast and facile pyrazolo[1,5-a]pyrimidine synthetic protocol has been established by the condensation of aminopyrazoles with 1,3-dicarbonyl components in AcOH/H2SO4 system. The pyrazolo[1,5-a]pyrimidine sulfides were selectively oxidized to the sulfones via a temperature-controlled stepwise oxidative fashion. The correlation between the substitution patterns of these pyrazolo[1,5-a]pyrimidines and their fluorescent spectroscopic properties were further examined, which provided the fundamentals for their potential applications in the development of new fluorescent probes. Red-shifts were easily achieved by the incorporation of unsaturated groups at the 5- and 7-positions, which suggested an approach for synthesizing long wavelength pyrazolo[1,5-a]pyrimidine dyes. The fluorescent spectroscopic properties were found to be sensitive to the hydroxy-containing and carbonyl-containing media such as alcohol and acetone, which helps to confirm the promising perspectives of further investigations in this area.
语种英语
WOS记录号WOS:000253896400014
出版者SPRINGER/PLENUM PUBLISHERS
源URL[http://ir.iccas.ac.cn/handle/121111/63433]  
专题中国科学院化学研究所
通讯作者Wu, Yan-Chao
作者单位1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
2.Nankai Univ, Inst Element Organ Chem, Tianjin 300071, Peoples R China
推荐引用方式
GB/T 7714
Wu, Yan-Chao,Li, Hui-Jing,Liu, Li,et al. Efficient construction of pyrazolo[1,5-a]pyrimidine scaffold and its exploration as a new heterocyclic fluorescent platform[J]. JOURNAL OF FLUORESCENCE,2008,18(2):357-363.
APA Wu, Yan-Chao,Li, Hui-Jing,Liu, Li,Wang, Dong,Yang, Hua-Zheng,&Chen, Yong-Jun.(2008).Efficient construction of pyrazolo[1,5-a]pyrimidine scaffold and its exploration as a new heterocyclic fluorescent platform.JOURNAL OF FLUORESCENCE,18(2),357-363.
MLA Wu, Yan-Chao,et al."Efficient construction of pyrazolo[1,5-a]pyrimidine scaffold and its exploration as a new heterocyclic fluorescent platform".JOURNAL OF FLUORESCENCE 18.2(2008):357-363.

入库方式: OAI收割

来源:化学研究所

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