Efficient construction of pyrazolo[1,5-a]pyrimidine scaffold and its exploration as a new heterocyclic fluorescent platform
文献类型：期刊论文
| 作者 | Wu, Yan-Chao1,2; Li, Hui-Jing1; Liu, Li1; Wang, Dong1; Yang, Hua-Zheng2; Chen, Yong-Jun1 |
| 刊名 | JOURNAL OF FLUORESCENCE
 |
| 出版日期 | 2008-03-01 |
| 卷号 | 18期号:2页码:357-363 |
| 关键词 | Fluorophore Heterocycle Fluorescence Pyrazolo[1 5-a]Pyrimidine |
| ISSN号 | 1053-0509 |
| DOI | 10.1007/s10895-007-0275-0 |
| 英文摘要 | An efficient, fast and facile pyrazolo[1,5-a]pyrimidine synthetic protocol has been established by the condensation of aminopyrazoles with 1,3-dicarbonyl components in AcOH/H2SO4 system. The pyrazolo[1,5-a]pyrimidine sulfides were selectively oxidized to the sulfones via a temperature-controlled stepwise oxidative fashion. The correlation between the substitution patterns of these pyrazolo[1,5-a]pyrimidines and their fluorescent spectroscopic properties were further examined, which provided the fundamentals for their potential applications in the development of new fluorescent probes. Red-shifts were easily achieved by the incorporation of unsaturated groups at the 5- and 7-positions, which suggested an approach for synthesizing long wavelength pyrazolo[1,5-a]pyrimidine dyes. The fluorescent spectroscopic properties were found to be sensitive to the hydroxy-containing and carbonyl-containing media such as alcohol and acetone, which helps to confirm the promising perspectives of further investigations in this area. |
| 语种 | 英语 |
| WOS记录号 | WOS:000253896400014 |
| 出版者 | SPRINGER/PLENUM PUBLISHERS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/63433]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wu, Yan-Chao |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China 2.Nankai Univ, Inst Element Organ Chem, Tianjin 300071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Yan-Chao,Li, Hui-Jing,Liu, Li,et al. Efficient construction of pyrazolo[1,5-a]pyrimidine scaffold and its exploration as a new heterocyclic fluorescent platform[J]. JOURNAL OF FLUORESCENCE,2008,18(2):357-363. |
| APA | Wu, Yan-Chao,Li, Hui-Jing,Liu, Li,Wang, Dong,Yang, Hua-Zheng,&Chen, Yong-Jun.(2008).Efficient construction of pyrazolo[1,5-a]pyrimidine scaffold and its exploration as a new heterocyclic fluorescent platform.JOURNAL OF FLUORESCENCE,18(2),357-363. |
| MLA | Wu, Yan-Chao,et al."Efficient construction of pyrazolo[1,5-a]pyrimidine scaffold and its exploration as a new heterocyclic fluorescent platform".JOURNAL OF FLUORESCENCE 18.2(2008):357-363. |
入库方式： OAI收割
来源：化学研究所
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