Finding multiple target optimal intervention in disease-related molecular network
文献类型：期刊论文
| 作者 | Yang, Kun1,2; Bai, Hongjun1,2; Qi Ouyang2; Lai, Luhua1,2; Tang, Chao2,3 |
| 刊名 | MOLECULAR SYSTEMS BIOLOGY
 |
| 出版日期 | 2008-11-01 |
| 卷号 | 4 |
| 关键词 | Anti-inflammatory Arachidonic Acid Metabolic Network Drug Efficacy Prediction Multiple Target Drug Design Network-based Drug Design |
| ISSN号 | 1744-4292 |
| DOI | 10.1038/msb.2008.60 |
| 英文摘要 | Drugs against multiple targets may overcome the many limitations of single targets and achieve a more effective and safer control of the disease. Numerous high-throughput experiments have been performed in this emerging field. However, systematic identification of multiple drug targets and their best intervention requires knowledge of the underlying disease network and calls for innovative computational methods that exploit the network structure and dynamics. Here, we develop a robust computational algorithm for finding multiple target optimal intervention (MTOI) solutions in a disease network. MTOI identifies potential drug targets and suggests optimal combinations of the target intervention that best restore the network to a normal state, which can be customer designed. We applied MTOI to an inflammation-related network. The well-known side effects of the traditional non-steriodal anti-inflammatory drugs and the recently recalled Vioxx were correctly accounted for in our network model. A number of promising MTOI solutions were found to be both effective and safer. |
| 语种 | 英语 |
| WOS记录号 | WOS:000261394500001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/63465]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Lai, Luhua |
| 作者单位 | 1.Peking Univ, Beijing Natl Lab Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Coll Chem & Mol Engn, Beijing 100871, Peoples R China 2.Peking Univ, Ctr Theoret Biol, Beijing 100871, Peoples R China 3.Univ Calif San Francisco, Dept Biopharmaceut Sci, San Francisco, CA 94143 USA |
| 推荐引用方式 GB/T 7714 | Yang, Kun,Bai, Hongjun,Qi Ouyang,et al. Finding multiple target optimal intervention in disease-related molecular network[J]. MOLECULAR SYSTEMS BIOLOGY,2008,4. |
| APA | Yang, Kun,Bai, Hongjun,Qi Ouyang,Lai, Luhua,&Tang, Chao.(2008).Finding multiple target optimal intervention in disease-related molecular network.MOLECULAR SYSTEMS BIOLOGY,4. |
| MLA | Yang, Kun,et al."Finding multiple target optimal intervention in disease-related molecular network".MOLECULAR SYSTEMS BIOLOGY 4(2008). |
入库方式： OAI收割
来源：化学研究所
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