The QRAR model study of beta-lactam antibiotics by capillary coated with cell membrane
文献类型：期刊论文
| 作者 | Yang, Gengliang1,2; Cao, Weimin2; Zhu, Tao2; Bai, Ligai2; Zhao, Yu2 |
| 刊名 | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
 |
| 出版日期 | 2008-09-15 |
| 卷号 | 873期号:1页码:1-7 |
| 关键词 | Cell Membrane Capillary Beta-lactam Antibiotics Qrar |
| ISSN号 | 1570-0232 |
| DOI | 10.1016/j.jchromb.2008.01.050 |
| 英文摘要 | With the accelerating development of new drugs, there is a great need for rapid and simple screening technologies. In this paper, a new in vitro method, capillary coated with cell membrane, was presented for drug screening based on the real biomembrane-drugs interaction, in which the cell membrane was applied to chromatography as pseudo-stationary phase directly. As the cell membrane was coated on the bare-fused capillary via sol-gel technology in our present work, it will be shown to be superior to other pseudo-stationary phases mimicking biological environment. Meanwhile, the quantitative retention-activity relationships (QRAR) model of beta-lactam antibiotics was studied through investigating the effect of the membrane coating amount and pH of running buffer on the retention behaviors of the drugs and the logarithm of octanol-water partition coefficient (log P) at pH 7.4 and pH 6.5 were also obtained for comparison. The results showed that the capillary coated with cell membrane could suit the study of QRAR model. (C) 2008 Published by Elsevier B.V. |
| 语种 | 英语 |
| WOS记录号 | WOS:000259837800001 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/63497]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yang, Gengliang |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China 2.Hebei Univ, Coll Pharm, Baoding 071002, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Gengliang,Cao, Weimin,Zhu, Tao,et al. The QRAR model study of beta-lactam antibiotics by capillary coated with cell membrane[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2008,873(1):1-7. |
| APA | Yang, Gengliang,Cao, Weimin,Zhu, Tao,Bai, Ligai,&Zhao, Yu.(2008).The QRAR model study of beta-lactam antibiotics by capillary coated with cell membrane.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,873(1),1-7. |
| MLA | Yang, Gengliang,et al."The QRAR model study of beta-lactam antibiotics by capillary coated with cell membrane".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 873.1(2008):1-7. |
入库方式： OAI收割
来源：化学研究所
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