Single-molecule study of lateral mobility of epidermal growth factor receptor 2/HER2 on activation
文献类型：期刊论文
| 作者 | Xiao, Zeyu1; Ma, Xinyong1; Jiang, Yaxin1; Zhao, Zilong1; Lai, Bo2; Liao, Jieying2; Yue, Jiachang2; Fang, Xiaohong1 |
| 刊名 | JOURNAL OF PHYSICAL CHEMISTRY B
 |
| 出版日期 | 2008-04-03 |
| 卷号 | 112期号:13页码:4140-4145 |
| ISSN号 | 1520-6106 |
| DOI | 10.1021/jp710302j |
| 英文摘要 | The transmembrane protein HER2, a member of the epidermal growth factor receptor family of tyrosine kinase, plays important roles in many fundamental cellular processes as well as the pathogenesis of many cancers. In this work, we have applied the single-molecule fluorescence microscopic method to study lateral mobility change of HER2 on activation by imaging and tracking individual GFP-tagged HER2 molecules on the membrane of living cells. The single HER2 molecules displayed different diffusion rates and modes. It was interesting to find that the mobility of HER2 increased upon stimulation by heregulin beta 1, the specific ligand of HER3. The faster diffusion was related to the tyrosine phosphorylation of HER2 or EGFR. The results provided new information for the understanding of HER2 activation and molecular mechanism of signal transduction through HER2/HER3 heterodimerization. |
| 语种 | 英语 |
| WOS记录号 | WOS:000254540900033 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/63633]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Fang, Xiaohong |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Inst Biophys, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiao, Zeyu,Ma, Xinyong,Jiang, Yaxin,et al. Single-molecule study of lateral mobility of epidermal growth factor receptor 2/HER2 on activation[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2008,112(13):4140-4145. |
| APA | Xiao, Zeyu.,Ma, Xinyong.,Jiang, Yaxin.,Zhao, Zilong.,Lai, Bo.,...&Fang, Xiaohong.(2008).Single-molecule study of lateral mobility of epidermal growth factor receptor 2/HER2 on activation.JOURNAL OF PHYSICAL CHEMISTRY B,112(13),4140-4145. |
| MLA | Xiao, Zeyu,et al."Single-molecule study of lateral mobility of epidermal growth factor receptor 2/HER2 on activation".JOURNAL OF PHYSICAL CHEMISTRY B 112.13(2008):4140-4145. |
入库方式： OAI收割
来源：化学研究所
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