Interactions between meso-tetrakis(4-(N-methylpyridiumyl))porphyrin TMPyP4 and DNA G-quadruplex of telomeric repeated sequence TTAGGG
文献类型：期刊论文
| 作者 | Zhang HuiJuan1; Wang XueFei2,3; Wang Peng2; Pang SiPing1; Ai XiCheng2; Zhang JianPing2 |
| 刊名 | SCIENCE IN CHINA SERIES B-CHEMISTRY
 |
| 出版日期 | 2008-05-01 |
| 卷号 | 51期号:5页码:452-456 |
| 关键词 | Tmpyp4 Dna G-quadruplex Spectroscopic Technique Binding Mode |
| ISSN号 | 1006-9291 |
| DOI | 10.1007/s11426-008-0051-2 |
| 英文摘要 | The binding properties between meso-tetrakis(4-(N-methylpyridiumyl))porphyrin (TMPyP4) and the parallel DNA G-quadruplex (G4) of telomeric repeated sequence 5'-TTAGGG-3' have been characterized by means of circular dichroism, steady-state absorption, steady-state fluorescence and picosecond time-resolved fluorescence spectroscopies. The binding constant and the saturated binding number were determined as 1.29x10(6) (mol/L)(-1) and 3, respectively, according to steably-state absorption spectroscopy. Based on the findings by the use of time-resolved fluorescence spectroscopic technique, it is deduced that TMPyP4 binds to a DNA G-quadruplex with both the thread-intercalating and end-stacking modes and at the saturated binding state, one TMPyP4 molecule intercalates into the intervals of G-tetrads while the other two stack to the ends of the DNA G-quadruplex. |
| 语种 | 英语 |
| WOS记录号 | WOS:000255985300008 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/63685]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang HuiJuan |
| 作者单位 | 1.Beijing Inst Technol, Sch Life Sci & Technol, Beijing 100081, Peoples R China 2.Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China 3.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang HuiJuan,Wang XueFei,Wang Peng,et al. Interactions between meso-tetrakis(4-(N-methylpyridiumyl))porphyrin TMPyP4 and DNA G-quadruplex of telomeric repeated sequence TTAGGG[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2008,51(5):452-456. |
| APA | Zhang HuiJuan,Wang XueFei,Wang Peng,Pang SiPing,Ai XiCheng,&Zhang JianPing.(2008).Interactions between meso-tetrakis(4-(N-methylpyridiumyl))porphyrin TMPyP4 and DNA G-quadruplex of telomeric repeated sequence TTAGGG.SCIENCE IN CHINA SERIES B-CHEMISTRY,51(5),452-456. |
| MLA | Zhang HuiJuan,et al."Interactions between meso-tetrakis(4-(N-methylpyridiumyl))porphyrin TMPyP4 and DNA G-quadruplex of telomeric repeated sequence TTAGGG".SCIENCE IN CHINA SERIES B-CHEMISTRY 51.5(2008):452-456. |
入库方式： OAI收割
来源：化学研究所
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