Formation of reversible shell cross-linked micelles from the biodegradable amphiphilic diblock copolymer poly(L-cysteine)-block-poly(L-lactide)
文献类型：期刊论文
| 作者 | Sun, Jing1,2; Chen, Xuesi1; Lu, Tiancheng1,2; Liu, Shi1,2; Tian, Huayu1,2; Guo, Zhaopei1,2; Jing, Xiabin1 |
| 刊名 | LANGMUIR
 |
| 出版日期 | 2008-09-16 |
| 卷号 | 24期号:18页码:10099-10106 |
| ISSN号 | 0743-7463 |
| DOI | 10.1021/la8013877 |
| 英文摘要 | A novel biodegradable diblock copolymer, poly(L-cysteine)-b-Poly(L-lactide) (PLC-b-PLLA), was synthesized by ring-opening polymerization (ROP) of N-carboxyanhydride of beta-benzyloxycarbonyl-L-Cysteine (ZLC-NCA) with amino-terminated Poly(L-lactide) (NH2-PLLA) as a macroinitiator in a convenient way. The diblock copolymer and its precursor were characterized by H-1 NMR, Fourier transform infrared (FT-IR), gel permeation chromatography (GPC), and X-ray photoelectron spectroscopy (XPS) measurements. The length of each block polymer could be tailored by molecular design and the ratios of feeding monomers. The cell adhesion and cell spread on the PZLC-b-PLLA and PLC-b-PLLA films were enhanced compared to those on pure PLA film. PLC-b-PLLA can self-assemble to form micelles in aqueous media. A pyrene probe is used to demonstrate the micelle formation of PLC-b-PLLA in aqueous solution. Due to the ease of disulfide exchange with thiols, the obtained micelles are reversible shell cross-linked (SCL) micelles. The morphology and size of the micelles are studied by dynamic light scattering (DLS) and environmental scanning electron microscopy (ESEM). |
| 语种 | 英语 |
| WOS记录号 | WOS:000259120500029 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/63711]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Changchun Inst Appl Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Jing,Chen, Xuesi,Lu, Tiancheng,et al. Formation of reversible shell cross-linked micelles from the biodegradable amphiphilic diblock copolymer poly(L-cysteine)-block-poly(L-lactide)[J]. LANGMUIR,2008,24(18):10099-10106. |
| APA | Sun, Jing.,Chen, Xuesi.,Lu, Tiancheng.,Liu, Shi.,Tian, Huayu.,...&Jing, Xiabin.(2008).Formation of reversible shell cross-linked micelles from the biodegradable amphiphilic diblock copolymer poly(L-cysteine)-block-poly(L-lactide).LANGMUIR,24(18),10099-10106. |
| MLA | Sun, Jing,et al."Formation of reversible shell cross-linked micelles from the biodegradable amphiphilic diblock copolymer poly(L-cysteine)-block-poly(L-lactide)".LANGMUIR 24.18(2008):10099-10106. |
入库方式： OAI收割
来源：化学研究所
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